grant
Immunologic and Imaging studies with TNF Therapy in Prodromal Synucleinopathies
NIHUS FederalResearch GrantFY2025(TNF)-α18-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2-Fluoro-2-deoxyglucoseActivities of Daily LivingActivities of everyday lifeAffectAnti-Tumor Necrosis Factor TherapyAtlasesAtrophic ArthritisAutoantigensAutoimmune DiseasesAutoimmune MechanismAutoimmune ProcessAutoimmune StatusAutoimmunityAutologous AntigensBasal GangliaBasal NucleiBiologicalBiological MarkersBloodBlood CirculationBlood Reticuloendothelial SystemBlood monocyteBloodstreamBody TissuesBrainBrain Nervous SystemCD 120b AntigenCD120b AntigensCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCachectinCatecholaminesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessClass II GenesClinicClinicalClinical Treatment MoabClinical TrialsClinical assessmentsClonalityCognitive ManifestationsCognitive SymptomsCollectionD2E7 antibodyDA NeuronDAT dopamine transporterDataDefectDiagnosisDiseaseDisease ProgressionDisorderDisseminated SclerosisDopamineDopamine neuronDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrugsEncephalonEpidemiological dataEpidemiology dataEvaluationFDG PETFOXP3FOXP3 geneFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryForkhead Box P3FoundationsFundingGI microbiomeGene ExpressionGeneral RadiologyGrantHLA Class II GenesHealth Care TechnologyHealth TechnologyHomeHydroxytyramineImageImmuneImmunesImmunochemical ImmunologicImmunoglobulin Enhancer-Binding ProteinImmunologicImmunologic SubtypingImmunologicalImmunologicallyImmunologicsImmunomodulationImmunophenotypingIndividualInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderIntracellular Communication and SignalingIsoformsJM2LeadLiquid substanceLocus CoeruleusLymphoid CellMHC Class IIMHC Class II GenesMHC ReceptorMR ImagingMR TomographyMRIMRI ScansMRIsMacrophage-Derived TNFMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMajor Histocompatibility Complex ReceptorMarrow monocyteMeasurementMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMemoryMetabolicMethodsMolecularMonoclonal AntibodiesMonocyte-Derived TNFMotorMultimodal ImagingMultiple SclerosisMyeloid CellsNAC precursorNF-kBNF-kappa BNF-kappaBNFKBNMR ImagingNMR TomographyNerve CellsNerve DegenerationNerve UnitNeural CellNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurocyteNeuron DegenerationNeuronsNuclear Factor kappa BNuclear Magnetic Resonance ImagingNuclear Transcription Factor NF-kBNucleus Pigmentosus PontisOutcomePARK1 proteinPARK4 proteinPBMCPETPET ScanPET imagingPETSCANPETTParalysis AgitansParkinsonParkinson DiseasePathologyPathway interactionsPatientsPatternPb elementPeptidesPeripheral Blood Mononuclear CellPersonsPharmaceutical PreparationsPlacebo ControlPlacebosPleocytosisPolysomnographyPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary ParkinsonismProcessProtein IsoformsProteinsREM Behavior DisorderREM Sleep Behavior DisorderRad.-PETRadiologyRadiology SpecialtyRandomizedRapid Eye Movement Behavior DisorderRapid Eye Movement Sleep Behavior DisorderReceptors, Tumor Necrosis Factor, Type IIRegulatory T-LymphocyteReportingResearch DesignRheumatoid ArthritisRoleSCURFINSNCASNCA proteinSPECTSPECT imagingSamplingScanningSelf-AntigensSham TreatmentSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle-Photon Emission-Computed Radionuclide TomographySiteSleep MonitoringSomnographyStudy TypeSubcellular ProcessSubstantia NigraSubstantia nigra structureSympathinsSymptomsSystemT cell receptor repertoire sequencingT cell receptor sequencingT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT4 CellsT4 LymphocytesTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTNFTNF ATNF AlphaTNF geneTNF therapyTNF-R2TNF-RIITNF-αTNFATNFBRTNFR p75TNFR2TNFR80TNFRSF1BTNFRSF1B ReceptorTNFRSF1B geneTNFαTestingTherapeutic EffectTissuesTranscription Factor NF-kBTregTumor Necrosis FactorTumor Necrosis Factor Beta ReceptorTumor Necrosis Factor Receptor 2Tumor Necrosis Factor Receptor 75Tumor Necrosis Factor Receptor Type 2Tumor Necrosis Factor TherapyTumor Necrosis Factor-alphaUpregulationZeugmatographya-syna-synucleinadalimumabalpha synucleinalpha synuclein genealphaSP22anti-TNF therapyanti-TNF-alpha therapyantigen based detectionantigen detectionantigen-specific T cellsasynautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactivitybasebasesbio-markersbiologicbiologic markerbiological signal transductionbiomarkerblue nucleusbody sensorbody worn sensorbowel inflammationbrain metabolismcell typeclinical imagingclinical outcome measurescognitive functioncohortcompare to controlcomparison controldaily living functiondaily living functionalitydesigndesigningdetect antigendigestive tract microbiomedigital healthdigital monitoringdigital technologydisease riskdisorder riskdopamine transporterdopaminergic neurondrug/agentdysbacteriosisdysbiosisdysbioticenteric microbiomeepidemiologic dataflow cytophotometryfluidfluorodeoxyglucosefluorodeoxyglucose PETfluorodeoxyglucose positron emission tomographyfunctional abilityfunctional capacitygastrointestinal microbiomeglobal gene expressionglobal transcription profilegut dysbiosisgut inflammationgut microbiomegut-associated microbiomeheavy metal Pbheavy metal leadhomesimage-based methodimagingimaging methodimaging modalityimaging studyimmune functionimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin vivoinflamed bowelinflamed gutinflamed intestineinflammation markerinflammatory disease of the intestineinflammatory disorder of the intestineinflammatory markerinhibitorinsightinsular sclerosisintervention effectintestinal autoinflammationintestinal biomeintestinal inflammationintestinal microbiomekappa B Enhancer Binding Proteinliquidlocus ceruleus structuremAbsmicrobial imbalancemonoclonal Absmonocytemotor symptommulti-modal imagingmulti-modal neuro-imagingmulti-modalitymulti-modality imagingmultimodal neuroimagingmultimodalitymultimodality imagingneural cell bodyneural degenerationneurobehavioral symptomneurodegenerationneurodegenerativeneurological degenerationneuromelaninneuronalneuronal cell bodyneuronal degenerationnon A-beta component of AD amyloidnon A4 component of amyloid precursornovelnuclear factor kappa betaoperationoperationspathwayplacebo controlledplacebo grouppositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreventpreventingprospectiverandomisationrandomizationrandomized, clinical trialsrandomly assignedregulatory T-cellsrheumatic arthritisscRNA sequencingscRNA-seqsham groupsham therapysingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell transcriptomic profilingsingle photon emission computed tomographysingle-cell RNA sequencingsleep measurementsleep polysomnographysocial rolesomastudy designstudy populationsynucleinopathythymus derived lymphocytetooltraffickingtranscriptometreatment grouptumor necrosis factor receptor superfamily, member 1Bwearable biosensorwearable sensorwearable sensor technologyα synuclein geneα-synα-synuclein
Description preview
Project Summary
Immunologic and Imaging studies with TNF Therapy in Prodromal Synucleinopathies is a pioneering,
prospective, randomized, double-blind parallel group study designed to assess the potential of anti-
TNF (adalimumab) to slow or prevent the emergence of motor and cognitive symptoms of synucleinopathy.
The trial is based on data from…
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