grant
Immune response to MCMV infection in the salivary glands
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 12 May 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AcuteAffectAnimal ModelAnimal Models and Related StudiesAnimalsBloodBlood Reticuloendothelial SystemBody TissuesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCITE sequencingCITE-seqCITEseqCMVCMV infectionCalibrationCancersCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular Indexing of Transcriptomes and Epitopes by SequencingCellular PhysiologyCellular ProcessCheckpoint inhibitorChronicCoACoenzyme ACytomegalic Inclusion DiseaseCytomegalovirusCytomegalovirus InfectionsCytotoxic cellDataDevelopmentDisease ProgressionDoseEffector CellEnvironmentEquilibriumEvolutionExhibitsFamily memberGeneHomologGoalsHCMVHHV-2HHV2HSV-2HSV2Herpes Simplex Virus 2Herpes Simplex Virus Type 2HerpesviridaeHerpesvirus 1 (beta), MuridHerpesvirus 2 (alpha), HumanHerpesvirus progenitalisHerpesvirusesHomologHomologous GeneHomologueHumanHuman (alpha) herpes virus 2Human Herpesvirus 2Human herpes simplex virus type 2IFNImmuneImmune checkpoint inhibitorImmune responseImmunesImmunityImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunomodulationImmunosuppressed HostImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentInclusion DiseaseIndividualInfectionInflammationInterferonsK lymphocyteLYT3Lymphatic cellLymphocyteLymphocyticLytotoxicityMalignant NeoplasmsMalignant TumorMiceMice MammalsModelingModern ManMouse CytomegalovirusMurid herpesvirus 1MurineMurine CytomegalovirusMusNK CellsNatural Killer CellsOrganPD 1PD-1PD-1 checkpoint pathwayPD-1 pathwayPD-1 signaling pathwayPD1PD1 checkpoint pathwayPD1 pathwayPD1 signaling pathwayPhasePopulationPositionPositioning AttributePregnant WomenPrimary InfectionProliferatingReceptor ProteinRegulationReportingResearchSalivary Gland Virus DiseaseSalivary Gland VirusesSalivary GlandsSiteSkinSortingSpecies SpecificitySpleenSpleen Reticuloendothelial SystemSubcellular ProcessSymptomsT-CellsT-LymphocyteT8 CellsT8 LymphocytesTherapeuticTissuesTropismViralViral DiseasesVirusVirus Diseasesanti programmed cell death protein 1 checkpoint pathwayanti programmed cell death protein 1 pathwayanti programmed cell death protein 1 signaling pathwaybalancebalance functioncellular indexing of transcriptomes and epitopes by single cell sequencingcytomegalovirus groupcytotoxicitydesigndesigningdevelopmentalexpectant motherexpectant womenexpecting motherexpecting womenexperimentexperimental researchexperimental studyexperimentsherpes simplex iiherpes virushost responsehuman alphaherpesvirus 2immune check point inhibitorimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic reactivity controlimmunomodulatoryimmunopathologyimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressed patientimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedindividuals who are pregnantinfection recurrenceinsightinterestlymph cellmalignancymigrationmodel of animalneonateneoplasm/cancerpathogenpeople who are pregnantpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingprogrammed cell death 1programmed cell death protein 1programmed death 1receptorrecruitrecurrent infectionrecurring infectionsle2systemic lupus erythematosus susceptibility 2those who are pregnantthymus derived lymphocytetooltumorviral infectionvirus infectionvirus-induced diseasewomen who are pregnant
Description preview
The β-herpesvirus human cytomegalovirus (HCMV) infects around 50% of the world population. Although it remains asymptomatic in healthy individuals, it is never completely cleared from the host and can cause recurrent infections, especially at times of immunosuppression. HCMV poses the biggest threat to pregnant women, neonates, and…
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