grant
Immune Regulation in Mycobacterial and Fungal Infections
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old18-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2-Fluoro-2-deoxyglucose21+ years oldAVP, Type IIAdolescentAdolescent YouthAdultAdult HumanAnti Mycobacterial AgentsAntigensAntimycobacterial AgentsAntiviral Protein, Type IIAssayAutoantibodiesAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBCG LiveBacille Calmette-GuérinBacillus Calmette GuérinBacteriaBioassayBiological AssayBloodBlood NeutrophilBlood Plasma CellBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemBlood TestsCD119CD119 AntigenCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCDw119 antigenCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCell Communication and SignalingCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell secretionCellular ImmunologyCellular SecretionCharacteristicsChildChild YouthChildren (0-21)Communicable DiseasesCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneCytotoxic cellDataDiseaseDisorderEDRF SynthaseEndothelium-Derived Growth Factor SynthaseExposure toExpression SignatureFree RadicalsFungus DiseasesGene ExpressionGene Expression ProfileGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGranulomaGranulomatous LesionGrowthGuanylyl Cyclase-Activating Factor SynthaseHematologic TestsHematological TestsHematology TestingHereditary DiseaseHost resistanceHumanIFNIFN-GammaIFN-gIFN-gamma receptor 1IFN-gammaRIFN-γIFN-γRIFNGIFNGRIFNGR1IFNGR1 geneIFNGR2IFNGR2 geneIFNGT1IFNγIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneIRF-1IRF1IRF1 geneImmune InterferonImmunomodulationInborn Genetic DiseasesIndividualInfantInfectionInfectious DiseasesInfectious DisorderInflammationInherited disorderInterferon GammaInterferon Gamma Receptor-1Interferon Regulatory Factor 1Interferon Type IIInterferon-Gamma Receptor 1InterferonsInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Intracellular Communication and SignalingK lymphocyteKineticsLungLung InflammationLung Respiratory SystemLung TBLung TuberculosisLymphatic TissueLymphoid TissueM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMTB vaccineMacacaMacaqueMacrophageMarrow NeutrophilMediatingMendelian susceptibility to mycobacterial diseaseMiceMice MammalsModelingModern ManMurineMusMyD32 proteinMycobacterial InfectionMycobacterium InfectionsMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMycosesMφNHP modelsNK CellsNO SynthaseNTM infectionNatural Killer CellsNeutrophilic GranulocyteNeutrophilic LeukocyteNitric Oxide SynthaseNitric-Oxide SynthetaseOperative ProceduresOperative Surgical ProceduresPET/CTPET/CT scanPathologyPathway interactionsPatientsPeptidesPhenotypePlasma CellsPlasmacytesPneumonitisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPredispositionProductionPropertyPublic HealthPublicationsPulmonary InflammationPulmonary TBPulmonary TuberculosisRNA ExpressionRNA SeqRNA sequencingRNAseqRegulatory T-LymphocyteResectedRoleSTAT1STAT1 geneSTAT91Scientific PublicationSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSiteSpecificitySurgicalSurgical InterventionsSurgical ProcedureSusceptibilityT cell differentiationT cell regulationT cell responseT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTB infectionTB vaccineTechniquesTestingTh-1 CellTh1 CellsTissue GrowthTranscriptionTregTuberculosisTuberculosis VaccinesType 1 Helper CellVaccine for TBVaccine for TuberculosisVaccinesWorkaccess to vaccinationaccess to vaccinesadulthoodanti-TB vaccineantigen-specific T cellsantimycobacterialautoimmune antibodyautoreactive antibodybiological signal transductioncell sortingchallenge in rhesus macaquescytokinedesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedisseminated TBdisseminated tuberculosisdrivingfluorodeoxyglucosefungal infectionfungus infectiongene expression patterngene expression signaturehereditary disorderheritable disorderimmune modulationimmune regulationimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin vivoinborn errorindexinginfected rhesus macaquesinfected rhesus monkeyinfection due to Mycobacterium tuberculosisinfection in rhesus macaquesinfection of rhesus macaquesinherited diseasesinherited genetic diseaseinherited genetic disorderinsightinterferon gamma receptorinterferon-stimulated gene factor 1juvenilejuvenile humankidslFN-Gammamortalitymtbneutrophilnon-tuberculosis mycobacterianon-tuberculosis mycobacterialnon-tuberculous mycobacterianon-tuberculous mycobacterialnon-tuberculous mycobacterial infectionnonhuman primate modelsnontuberculosis mycobacterialnontuberculous mycobacterianontuberculous mycobacterialnovelontogenypathwayplasmocytepolarized cellpositron emission computed tomographypreventpreventingprotective effectregulatory T-cellsresponserhesus challengerhesus macaque challengerhesus monkey infectionscRNA sequencingscRNA-seqself reactive antibodysingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesurgerythymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtuberculosis infectiontuberculous spondyloarthropathyvaccination accessvaccination availabilityvaccine accessvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine availabilityvaccine candidatevaccine candidates against tuberculosisvaccine developmentyoungster
Description preview
Mycobacterium tuberculosis (Mtb) infection is one of the leading causes of global mortality due to infectious disease. The only available vaccine for tuberculosis (TB) is Bacillus Calmette-Guerin (BCG), which protects infants against severe forms of TB, but does little to prevent disease in adolescents and adults. A highly effective TB vaccine…
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