grant
Immune Function and the Progression to Type 1 Diabetes
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 30 Sept 1997Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AddressAgeAntigensAutoantibodiesAutoimmuneAutoimmune DiseasesB9 endocrine pancreasBioinformaticsBiologic ModelsBiological MarkersBiological ModelsBiomedical ResearchBiometricsBiometryBiostatisticsBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesBrittle Diabetes MellitusCell BodyCell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular modelClinical DataClinical TreatmentClinical Trials NetworkCollectionCommunicationComplementComplement ProteinsComplexConsentCore FacilityCryofixationCryopreservationCuesDataData BasesData SetDatabasesDefectDevelopmentDiabetes MellitusDiathesisDifferentiated GeneDiseaseDisease susceptibilityDisorderEndocrine PancreasEndothelial CellsEnhancersEnvironmentEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExonsExpression SignatureFloridaFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGWA studyGWASGene ExpressionGene Expression ProfileGenesGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic RiskGenomeGenotypeGoalsGrantHeterogeneityHistoryHumanHumulin RIDDMImaging technologyImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune ToleranceImmune responseImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologic SubtypingImmunologic ToleranceImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsImmunophenotypingIn SituIndividualInflammationInflammatoryInsulinInsulin-Dependent Diabetes MellitusIntervention TrialInterventional trialIslands of LangerhansIslet CellIslets of LangerhansJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLife StyleLifestyleLinkLymph Node Reticuloendothelial SystemLymph node properLymphaticLymphatic TissueLymphatic nodesLymphoid TissueMeasurementMediatingModalityModel SystemModern ManMolecularMonitorMotilityNational Institutes of HealthNatural HistoryNeighborhoodsNesidioblastsNovolin ROrganOrgan DonorPancreasPancreaticPancreatic IsletsPancreatic beta CellPancreatic β-CellPars endocrina pancreatisPathogenesisPathologicPathway interactionsPatientsPeer ReviewPeripheralPhenotypeProcessProteomicsRaceRacesRecombinant DNA TechnologyRecording of previous eventsRecruitment ActivityRegular InsulinResearchResearch ResourcesResolutionResourcesRiskRisk-associated variantSamplingSeriesSerologySiteSliceSpleenSpleen Reticuloendothelial SystemStructure of beta Cell of isletSubcellular ProcessSudden-Onset Diabetes MellitusSystemT-Cell ActivationT-Cell Receptor GenesT-CellsT-LymphocyteT-cell receptor repertoireT1 DMT1 diabetesT1DT1DMTCR repertoireTcR GenesTechnologyTestingTherapeutic AgentsTherapeutic InterventionTissue SampleTissue imagingTissuesTransplantationType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited States National Institutes of HealthUniversitiesVariantVariationactivate T cellsactive recruitmentagesautoimmune antibodyautoimmune attackautoimmune conditionautoimmune destructionautoimmune disorderautoimmune pathogenesisautoimmunity diseaseautoreactive antibodybio-markersbiobankbiologic markerbiomarkerbiorepositorycausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell killingcell stresscellular differentiationclinical interventionclinical therapycold preservationcold storagecomplementationdata basedata modalitiesdata sharingdesigndesigningdevelopmentaldiabetesdisease modeldisorder modeldraining lymph nodeepigeneticallyexperienceflow cytophotometrygain of function mutationgene expression patterngene expression signaturegenetically engineeredgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyhistorieshost responsehuman subjecthuman tissueiPSiPSCiPSCsimmune activationimmune functionimmune system responseimmune system toleranceimmune unresponsivenessimmunogenimmunological paralysisimmunoresponseimprovedinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativeinnovative technologiesinsightinsulin dependent diabetesinsulin dependent type 1intervention therapyisletislet autoantibodyislet cell antibodyjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesliability to diseaselife spanlifespanlymph glandlymph nodeslymphnodesmigrationmolecular phenotypemortalitynew markernovelnovel biomarkernovel markerpancreas beta cellpancreas β cellpancreatic b-cellpathwayperipheral bloodphenotypic datapolygenetic risk scorespolygenic risk scoreprecision medicineprecision-based medicinepreservationpreventpreventingprogramspromoterpromotorracialracial backgroundracial originregional lymph noderesolutionsrisk allelerisk generisk genotyperisk locirisk locusrisk variantself reactive antibodysexsuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutically effectivethymus derived lymphocytetissue resourcetraffickingtranscriptional profiletranscriptional signaturetransplanttrial regimentrial treatmenttype I diabetestype one diabeteswhole genome association analysiswhole genome association study
Description preview
Type 1 diabetes (T1D) is a disorder that arises following the autoimmune destruction of insulin producing
pancreatic β-cells. Previous studies, including nearly 120 peer reviewed-articles supported by this P01 over the
current grant cycle, have demonstrated that individuals with or at increased-risk for T1D display a series of innate
and adaptive…
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