grant
Immune dysregulation mechanisms of persistent post-COVID19 olfactory dysfunction
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAfferent NeuronsAirway mucosaAnosmiaAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryArchitectureAutoregulationBIGH3Biological Response ModifiersBiologyBiomodulatorsBlood monocyteCD115CD115 GeneCD87CDB1CDGG1COVID anosmiaCOVID associated anosmiaCOVID related anosmiaCOVID smell lossCOVID-19COVID-19 anosmiaCOVID-19 associated anosmiaCOVID-19 associated smell lossCOVID-19 induced anosmiaCOVID-19 olfactory dysfunctionCOVID-19 related anosmiaCOVID-19 related olfactory dysfunctionCOVID-19 smell lossCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID-19-mediated anosmiaCOVID-related smell lossCOVID19 virusCSD1CSD2CSD3CSF1RCSF1R geneCSFMRCV-19CacosmiaCell BodyCell DifferentiationCell Differentiation processCellsCharacteristicsChemotactic CytokinesChronicClinicalClinical DataClinical SciencesCoV-2CoV2Colony Stimulating Factor 1 Receptor GeneComputing MethodologiesCoronavirus Infectious Disease 2019Cystic FibrosisDataDevelopmentDiseaseDisorderDistorted TasteDrynessDysfunctionDysgeusiaDysosmiaEngineering / ArchitectureEnvironmentEpithelial CellsEpitheliumEsthesiaFunctional disorderGene TranscriptionGenerationsGenesGenetic TranscriptionGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGlycoproteinsGoblet CellsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGustationHomeostasisHomologous Chemotactic CytokinesHumanImmuneImmune MediatorsImmune Mediators/ModulatorsImmune infiltratesImmunesImmunologic SubtypingImmunophenotypingImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroIncidenceInfiltrationInflammationInflammation MediatorsInflammatoryIntercrinesLCD1Linoleic AcidsLipidsLiquid substanceLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019MacrophageMalignant MelanomaMapsMarrow monocyteMeasuresMediatorMelanomaMethodsMiceMice MammalsModern ManMolecularMucoviscidosisMurineMusMyelogenousMyeloidMφNasalNasal EpitheliumNasal MucosaNasal Passages NoseNatural regenerationNerve Impulse TransmissionNerve TransmissionNeuroepithelialNeuroglial NeoplasmNeuroglial TumorNeuronal TransmissionNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic InfiltrateNon-metastaticNonmetastaticNoseOlfactionOlfactory Epithelial CellOlfactory MucosaPLAURPLAUR geneParageusiaPathway interactionsPatientsPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPopulationProgenitor CellsProliferatingProteinsRNA ExpressionRecoveryRegenerationReportingRespiratory MucosaRespiratory System, Nose, Nasal PassagesSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 induced anosmiaSARS-CoV-2 mediated anosmiaSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SIS cytokinesSamplingSensationSensorySensory NeuronsSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SeveritiesSmellSmell PerceptionSourceSteroid CompoundSteroid ResistanceSteroid ResistantSteroid therapySteroidsStructure of mucous membrane of noseSupporting CellSwabSymptomsSyndromeSystemTGFBITGFBI geneTasteTaste PerceptionTestingTimeTranscriptionU-PAU-Plasminogen ActivatorUPARURKRUpper Respiratory InfectionsUpper Respiratory Tract InfectionUrinary Plasminogen ActivatorUrokinaseUrokinase Plasminogen ActivatorUrokinase-Type Plasminogen ActivatorViralWuhan coronavirusafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionanosmia associated with COVID-19anosmia in COVID-19anosmia with COVID-19anosphrasiaapoptosis of neuronal cellsaxon signalingaxon-glial signalingaxonal signalingc-FMSc-fms Genesc-fms Proto-Oncogenescell typecellular differentiationcellular targetingchemoattractant cytokinechemokinechronic COVIDchronic COVID-19chronic novel coronavirus disease 2019chronic rhinosinusitiscomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcoronavirus disease 2019coronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease-19coronavirus disease-19 viruscoronavirus infectious disease-19developmentalexperiencefluidfollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectionglia signalingglial signalingglial-derived tumorglioblastoma multiformegustatory perceptiongustatory processinggustatory responsehCoV19human subjectimmune cell infiltrateimmune suppressionimmune suppressive activityimmune suppressive functionimmune suppressive macrophagesimmunosuppressive activityimmunosuppressive functionimmunosuppressive macrophagesimmunosuppressive responseineffective therapiesineffective treatmentinflammatory environmentinflammatory mediatorinflammatory milieuinsightlipid mediatorliquidlong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019loss of smellmonocytenCoV2nasal obstructionnasal swabnerve signalingneural signalingneuroepitheliumneuroglia neoplasmneuroglia tumorneuron apoptosisneuron developmentneuronal apoptosisneuronal cells programmed cell deathneuronal developmentneuronal signalingneuronal survivalneurons programmed cell deathneurotransmissionneurotrophic factorneurotrophinneutrophinnovelodor perceptionolfactory dysfunction following COVID-19olfactory dysfunction following SARS-CoV-2olfactory dysfunction in COVID-19olfactory dysfunction in SARS-CoV-2olfactory lossolfactory perceptionolfactory sensory neuronsonline registrypathophysiologypathwaypersistent COVID-19post COVID syndromepost COVID-19 syndromepost SARS-CoV-2 infectionpost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-COVIDpost-COVID-19post-acute phases of COVID-19post-coronavirus disease 2019previous COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionprogenitor cell proliferationprogenitor proliferationprogrammed cell death of neuronal cells by apoptosisprogrammed cell death of neurons by apoptosisprolonged COVID-19 symptomsprotein Brecruitregeneraterespiratoryresponse to therapyresponse to treatmentsevere acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssmell loss associated with COVID-19spongioblastoma multiformestem and progenitor cell proliferationstem cell proliferationstem cellstaste processingtaste responsetherapeutic agent developmenttherapeutic developmenttherapeutic responsetherapy responsetooltreatment responsetreatment responsivenesstumor
Description preview
PROJECT SUMMARY:
The sudden loss of smell and taste are among the defining features of COVID-19 that set it apart from other
viral respiratory syndromes with an incidence of up to 70% with some SARSCoV2 variants. Importantly, in
some patients smell and taste disturbances persist for longer than 12 months after recovery from COVID-19.
Furthermore,…
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