grant
Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance
NIHUS FederalResearch GrantFY20260-11 years old12-20 years oldAIDS VirusAIDS focused researchAIDS related researchAIDS researchAIDS scienceAIDS specific researchAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdaptive Immune SystemAddressAdolescenceAnti-viral ResponseBindingBioinformatics coreBioinformatics research coreBioinformatics resource coreBloodBlood Reticuloendothelial SystemBody TissuesBone-Derived Transforming Growth FactorCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCSIFCSIF-10Cellular Immune FunctionChildChild YouthChildhoodChildren (0-21)CollaborationsCommunicationComplexCytokine Synthesis Inhibitory FactorDataDevelopmentDiseaseDisorderEnvironmentExperimental DesignsFutureGoalsHIVHIV InfectionsHIV cureHIV focused researchHIV functional cureHIV in childrenHIV in pediatric populationsHIV infected childrenHIV infection persistenceHIV investigationHIV persistenceHIV positive childrenHIV related researchHIV researchHIV scienceHIV specific researchHIV viral infectionHIV viral persistenceHIV virus infectionHIV+ childrenHIV-1 cureHIV-1 functional cureHIV-1 infectionHIV-1 persistenceHIV/AIDS cureHost FactorHost Factor ProteinHuman Immunodeficiency VirusesIL-10IL10IL10AImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunesImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologyImmunomodulationIn VitroInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1Innate Immune SystemIntegration Host FactorsInterleukin 10 PrecursorInterleukin-10InvestigationInvestigation on HIVInvestigatorsKnowledgeLAV-HTLV-IIILYT3LinkLymphadenopathy-Associated VirusMaintenanceMentorsMetabolicMilk Growth FactorMissionModelingMolecular InteractionMorbidityNational Institutes of HealthNatureNeonatalOutputPathologyPathway interactionsPerinatal InfectionPlatelet Transforming Growth FactorPre-Clinical ModelPreclinical ModelsPrimatesPrimates MammalsResearchResearch PersonnelResearch ResourcesResearchersResourcesRoleSIVScientistSimian Immunodeficiency VirusesSystemT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTGF BTGF-betaTGF-βTGFbetaTGFβTestingThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneUnited States National Institutes of HealthViral LatencyViremiaVirusVirus LatencyVirus-HIVacquired immune systemadolescence (12-20)antiretroviral therapyantiretroviral treatmentchildhood HIVchildren infected with HIVchildren living with HIVchildren living with human immunodeficiency viruschildren with HIVclinical trial protocolcohortcurative interventioncurative therapeuticcurative therapycurative treatmentsdetermine efficacydevelopmentalefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperienceexperimentexperimental researchexperimental studyexperimentshigh dimensionalityhuman immunodeficiency virus curehuman immunodeficiency virus infectionhuman immunodeficiency virus persistencehuman immunodeficiency virus researchimmune functionimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin vivoinfected with HIVinfected with human immunodeficiency virusinsightkidsmedical collegemedical schoolsmicrobialmortalitymultidisciplinarymultiomicsmultiple omicsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypanomicspathogenpathwaypediatricpediatric HIVpediatric departmentpediatric human immunodeficiency viruspediatric populations infected with HIVperinatal HIVperinatal periodperinatal phasepersistent HIVpersistent HIV-1persistent human immunodeficiency viruspressureprogramsresearch addressing HIVresearch in HIVresearch into HIVresearch on HIVresearch on human immunodeficiency virusresearch to address HIVschool of medicinescience on HIVscience to address HIVsingle cell technologysocial rolestudies on HIVsynergismtool developmentviraemiaviral reboundviral sepsisvirus host interactionvirus reboundvirusemiayoungster
Description preview
ABSTRACT - Overall
New perinatal HIV infections continue, at a rate of about one every 3-4 minutes, 400 every day, and 3000
every week. For children living with HIV (CLWH), antiretroviral therapy (ART) greatly reduces mortality and
morbidity; however, viral rebound quickly ensues if ART is stopped. HIV persistence in a latent reservoir in
CD4+ T…
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