grant
Immune Data Science Core (IDS Core)
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 24 Jul 2019Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAmniotic FluidAntibodiesAntigen ReceptorsAntigen-Antibody ComplexAntigenic DeterminantsApplied ResearchApplied ScienceAqua AmniiAssayAutopsyBayesian ModelingBayesian adaptive designsBayesian adaptive modelsBayesian belief networkBayesian belief updating modelBayesian frameworkBayesian hierarchical modelBayesian network modelBayesian nonparametric modelsBayesian spatial data modelBayesian spatial image modelsBayesian spatial modelsBayesian statistical modelsBayesian tracking algorithmsBindingBinding DeterminantsBioassayBiologic ModelsBiological AssayBiological MarkersBiological ModelsBiologyBlood PlasmaBody SystemBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCMVCategoriesCell BodyCellsCellular AssayComplexComputational BiologyCreativenessCustomCytomegalovirusDataData AnalysesData AnalysisData BasesData ScienceData Science CoreData Science Resource CoreData SetDatabasesDependenceDiseaseDisorderEngineeringEnsureEpitopesExperimental DesignsExpression SignatureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene Expression ProfileGenerationsGenesHCMVImmuneImmune ComplexImmunesImmunochemical ImmunologicImmunocompetentImmunofluorescence MicroscopyImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologicImmunologic FactorsImmunologicalImmunological FactorsImmunologicallyImmunologicsImmunologyImmunology procedureInvestigatorsKnowledgeLinkLiquor AmniiM mulattaM. mulattaMacaca mulattaMacaca rhesusMath ModelsMetadataMethodsModel SystemModelingMolecular InteractionOrgan SystemOutcomeOutcome MeasurePassive ImmunizationPatternPlasmaPlasma SerumProbabilistic ModelsProbability ModelsProcessProteomicsProtocolProtocols documentationQuality ControlReproducibilityResearchResearch PersonnelResearch ResourcesResearchersResourcesReticuloendothelial System, Serum, PlasmaRhesus MacaqueRhesus MonkeySalivaSalivary Gland VirusesSample SizeStaining methodStainsStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStatistical ModelsStructureT-Cell DepletionT-cell depletion therapyT-cell receptor repertoireT-lymphocyte depletion therapyT4 CellsT4 LymphocytesTCR repertoireTestingTimeTissuesTransmissionUrineVaccinesVariantVariationViralViral BurdenViral LoadViral Load resultViral SheddingViral VaccinesVirusVirus SheddingVisualizationWorkbio-markersbiologic markerbiomarkercell assaycell typecomputational resourcescomputer biologycomputing resourcescongenital CMVcongenital cytomegaloviruscongenital cytomegalovirus infectioncreativitycustomscytokinecytomegalovirus groupdata basedata ingestiondata interpretationdata visualizationdesigndesigningdimension reductiondimensionality reductionexperienceexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygene expression patterngene expression signaturehigh dimensionalityimmune competentimmune response to vaccinationimmune response to vaccinesimmunogenicityimmunologic assayimmunologic assay/testimmunologic substanceimmunological substanceinterestmathematic modelmathematical modelmathematical modelingmeasurable outcomemeta datamultiplex assaymutantnecropsynon-human primatenonhuman primatenoveloutcome measurementpassive vaccinationpostmortempreventpreventingprimary outcomeprogramsreduce data dimensionreduce dimensionalitysaliva samplesalivary samplescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstatistical analysisstatistical linear mixed modelsstatistical linear modelsstatisticstooltranscriptional profiletranscriptional signaturetranscriptomicstransmission blockingtransmission processvaccine associated immune responsevaccine efficacyvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccinologyviral transmissionvirologyvirus transmission
Description preview
ABSTRACT – IMMUNE DATA SCIENCE (IDS) CORE
The Immune Data Science (IDS) Core will be responsible for analysis of high-dimensional immune data sets
generated by Projects 1-3 and the Model Systems (MODS) Core. The objectives of the analysis are to
address 1) viral factors contributing to transmission, 2) immune factors contributing to blocking…
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