grant
Immune analysis of the HBsAg seroclearance response terminating chronic HBV
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 20 Nov 2024Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY202521+ years oldAcute HepatitisAdultAdult HumanAffectAgonistAnti-viral TherapyAntigen PresentationAu antigenAustralia AntigenBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Communication and SignalingCell SignalingCell Surface AntigensCellsCessation of lifeChronic Hepatitis BCirrhosisClinicalClinical ResearchClinical StudyClinical Treatment MoabClinical TrialsCollaborationsDataDeathDendritic CellsDiagnosisDiseaseDisorderDissectionDrugsElementsEnvironmentEventFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFutureGrantHBVHBV cureHBV diseaseHBV functional cureHBV infected individualsHBV infectionHBV infection in patientsHBV infection in peopleHBV patientsHBsAgHealthHepBHepaticHepatic CancerHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatitis BHepatitis B InfectionHepatitis B Surface AntigensHepatitis B VirusHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHumanImmuneImmune responseImmunesImmunityImmunochemical ImmunologicImmunocompetenceImmunologicImmunologic CompetenceImmunologicalImmunological CompetenceImmunological Surface MarkersImmunologicallyImmunologicsInfectionInjury to LiverIntracellular Communication and SignalingLaboratoriesLifeLiverLiver CellsLiver Cells CarcinomaLiver diseasesLiver lesion biopsyLong-term infectionLymphoidMalignant neoplasm of liverMediatingMedicationMiceMice MammalsModelingModern ManMonoclonal AntibodiesMurineMusOutcomePBMCPathway interactionsPatientsPeripheral Blood Mononuclear CellPersonsPharmaceutical PreparationsPhenocopyPhenotypePositionPositioning AttributePrimary Malignant Neoplasm of LiverPrimary carcinoma of the liver cellsPrimary liver cancerProteomicsPublishingRelapseResolutionRiskSamplingSampling StudiesSignal TransductionSignal Transduction SystemsSignalingSurface AntigensT cell responseT-Cell ActivationT-CellsT-LymphocyteT-cell diversityT4 CellsT4 LymphocytesTestingTherapeuticTimeTissue imagingUnited StatesVeiled CellsViralViral Hepatitis BWorkactivate T cellsadulthoodage associatedage correlatedage dependentage linkedage relatedage specificanalogattributable deathattributable mortalitybiological signal transductionbiomarker identificationcell typechronic HBV infectionchronic hepatitis B infectionchronic hepatitis B virus infectionchronic infectionchronic infections with hepatitis B viruschronically infected with HBVchronically infected with hepatitis Bcirrhoticdrug/agentexperienceflow cytophotometryhep Bhepatic body systemhepatic damagehepatic diseasehepatic injuryhepatic organ systemhepatitis B curehepatitis B functional curehepatitis B patientshepatitis B viral infectionhepatitis B virus curehepatitis B virus diseasehepatitis B virus functional curehepatitis B virus infected individualshepatitis B virus infectionhepatitis B virus infection in patientshepatitis B virus infection in peoplehepatopathyhost responsehuman modelidentification of biomarkersidentification of new biomarkersimmune system responseimmunoresponseimprovedindividuals with HBVindividuals with hepatitis Binfected with HBVinfected with hepatitis Binfected with hepatitis B virusinfection with HBVinfection with hepatitis B virusliver biopsyliver cancerliver carcinomaliver damageliver disorderliver imagingliver injuryliver malignancyliver scanningmAbsmalignant liver tumormarker identificationmodel of humanmonoclonal Absmouse modelmultiomicsmultiple omicsmurine modelnew approachesnovel approachesnovel strategiesnovel strategypanomicspathogenpathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespatients with HBVpatients with hepatitis Bpeople with HBVpeople with hepatitis Bpersistent infectionresolutionsresponseseroconversiontherapeutic targetthymus derived lymphocytetranscriptome profilingtranscriptomic profilingviral infectious disease treatment
Description preview
PROJECT SUMMARY
Chronic infection with hepatitis B virus (HBV) is a major global problem affecting an estimated 300 million people.
HBV-induced immune-mediated progressive liver injury and primary liver cancer led to a WHO-estimated
820,000 deaths in 2019. While clearance of the HBV surface antigen (HBsAg) defines clinical cure and reduces
all…
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