grant
Imaging the Respiratory Effects of Truncal Adiposity in Acute Hypoxemic Respiratory Failure
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 10 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AI basedAbdomenAddressAdipose tissueAffectAirway imagingAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsBiologicalBiological MarkersBiomechanicsBody WeightBreathing MechanicsCAT scanCT X RayCT XrayCT imagingCT scanCaringCharacteristicsChestClinicalClinical ManagementComputed TomographyDataDorsal PositionDrug or chemical Tissue DistributionEarly identificationEarly treatmentEffectivenessEsophagusFamily suidaeFatty TissueFutureGasesGeneral RadiologyGeometryGoalsHigh PrevalenceHospitalsHourImageImage AnalysesImage AnalysisImaging DeviceImaging InstrumentImaging ToolImpairmentIndividualInjuryLinkLungLung ParenchymaLung Respiratory SystemLung TissueLung damageManometryManometry BiochemistryMeasurementMeasuresMechanical ventilationMechanicsModelingMorbidityMorbidity - disease rateMorphologyObesityOutcomePatient MonitoringPatientsPatternPeripheralPhenotypePhysiologicPhysiologicalPigsPleuralPopulationPositive End-Expiratory PressurePositive-Pressure RespirationPrecision careProne PositionProspective, cohort studyPublic HealthPublishingRadiologyRadiology SpecialtyResearchRespiratory MechanicsRespiratory physiologyRiskRisk FactorsScanningSeveritiesSeverity of illnessStretchingStructure of parenchyma of lungSuidaeSupine PositionSwineTechniquesTestingThoraceThoracicThoraxTissue DistributionTitrationsTomodensitometryUncertaintyUnited StatesVentilatorVisualizationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyacute hypoxemic respiratory failureacute hypoxic respiratory failureacute onset hypoxemic respiratory failureadiposeadiposityartificial intelligence basedbio-markersbiologicbiologic markerbiomarkerbiomechanicalbody positioncatscanclinical infrastructurecomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycorpulencecustomized therapycustomized treatmentdisease severitydoubtearly therapyelectrical impedance tomographyhealth knowledgehealthy volunteerimage evaluationimage interpretationimage registrationimagingimaging Segmentationimaging studyimprovedindividualized careindividualized medicineindividualized patient careindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinjuriesinsightinstrumentlung injurylung volumemechanicmechanicalmechanical loadmechanical respiratory assistmechanically ventilatedmodel of animalnon-contrast CTnoncontrast CTnoncontrast computed tomographynovelobese patientsobesity biomarkersobesity-related biomarkerspatient specific therapiespatient specific treatmentpatients with obesitypersonalized carepersonalized patient carepig modelpiglet modelporcineporcine modelpositive pressure breathingpressurepublic health relevancepulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryquantitative imagingrespiratoryrespiratory functionrespiratory imagingresponseresponse to therapyresponse to treatmentstandard carestandard treatmentsuidswine modeltailored medical treatmenttailored therapytailored treatmenttherapeutic responsetherapy responsetooltreatment responsetreatment responsivenessunique treatmentventilationwhite adipose tissueyellow adipose tissue
Description preview
PROJECT SUMMARY
Obesity affects more than 40% of the United States population and is a major risk factor for acute hypoxemic
respiratory failure (AHRF). AHRF patients with obesity have more ventilator-related morbidity and may be less
responsive to standard respiratory care treatments, such as prone position and positive end expiratory pressure…
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