grant
Imaging Protein Synthesis on the Ribosome using Single-Molecule FRET
Organization ST. JUDE CHILDREN'S RESEARCH HOSPITALLocation MEMPHIS, UNITED STATESPosted 1 May 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AcuteAddressAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsBacteriaBiophysicsCancersCell Communication and SignalingCell SignalingClinicalClinical TreatmentConsumptionCryo-electron MicroscopyCryoelectron MicroscopyCuesDevelopmentDrug resistanceEffectivenessElectron CryomicroscopyElementsEvolutionGene ExpressionGoalsHumanImageIndividualInterventionIntracellular Communication and SignalingInvestigationKineticsKnowledgeMalignant NeoplasmsMalignant TumorMessenger RNAMiscellaneous AntibioticModern ManMolecularNatural ProductsNon-Polyadenylated RNAPhasePhysiologicPhysiologicalPredispositionProcessProductionProtein BiosynthesisProteinsProteomeRNARNA Gene ProductsReactionRegulationResearchResistance to antibioticsResistant to antibioticsResolutionRibonucleic AcidRibosomal InteractionRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesSignal TransductionSignal Transduction SystemsSignalingSpecificityStructure-Activity RelationshipSusceptibilitySystemTherapeuticTimeTranslationsantibiotic drug resistanceantibiotic resistantbiological signal transductionbiophysical approachesbiophysical foundationbiophysical methodologybiophysical methodsbiophysical principlesbiophysical sciencesbiophysical techniqueschemical structure functionclinical efficacyclinical interventionclinical therapycombatconformational conversionconformational transitioncryo-EMcryoEMcryogenic electron microscopydevelopmentaldrug actiondrug resistanteffective therapyeffective treatmentemerging pathogenfluorescence imagingfluorescent imaginghuman diseaseimagingimprovedinfectious disease treatmentinsightmRNAmalignancymicrobial diseasenaturally occurring productneoplasm/cancernew approachesnew pathogennovelnovel approachesnovel pathogennovel strategiesnovel strategypathogenprotein complexprotein synthesisresistance to Drugresistant to Drugresolutionssingle moleculesingle-molecule FRETsingle-molecule fluorescence resonance energy transfersmFRETsmall moleculestructure function relationshiptranslationtrial regimentrial treatment
Description preview
PROJECT ABSTRACT:
The mechanism and regulation of protein synthesis determines the diversity and capacity of the cellular
proteome. At the center of this regulation is the ribosome - a megadalton RNA-protein complex composed of
two-subunits – which integrates a wide variety of cellular signals. The ribosome’s exquisite sensitivity to
regulatory…
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