grant
Imaging Neurodegeneration in Multiple Sclerosis
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Apr 2013Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AccelerationAcuteAddressAgeAgingAnatomic SitesAnatomic structuresAnatomyAnisotropyAtrophicAtrophyAxonBenefits and RisksBlood VesselsBody TissuesBrainBrain Nervous SystemBrain imagingCNS Nervous SystemCaringCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous SystemCerebrovascular CirculationCerebrumChronicClinicalClinical TrialsDWI (diffusion weighted imaging)DWI-MRIDecision MakingDemyelinationsDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisease ProgressionDisorderDisseminated SclerosisDistantDoppler OCTEncephalonEvaluationExhibitsFe elementFutureGliaGlial CellsGoalsGrantHortega cellImageImmuneImmune infiltratesImmunesIndividualInflammationInner Plexiform LayerIntermediary MetabolismIntracellular Communication and SignalingIronKolliker's reticulumLesionLifeLymphatic cellLymphocyteLymphocyticMR ImagingMR TomographyMRIMRI ScansMRIsMS patientMS treatmentMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMagnetismMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMeningealMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolic stressMetabolismMethodsMicrogliaMicroscopicMonitorMultiple SclerosisMyelinNMR ImagingNMR TomographyNerve CellsNerve DegenerationNerve UnitNeural CellNeuraxisNeurocyteNeurogliaNeuroglial CellsNeurologicNeurologicalNeuron DegenerationNeuronal DysfunctionNeuronsNon-neuronal cellNonneuronal cellNuclear Magnetic Resonance ImagingO elementO2 elementOCT TomographyOCT angiographyOCTAOptic NeuritisOptical Coherence TomographyOutcomeOutcome AssessmentOutcome MeasureOxygenPaperPathologyPeripheralPersonsPhenotypePrecision carePredispositionProcessPublicationsRaceRacesRelapseRelaxationResolutionRetinaRetinal Blood VesselsRetinal VesselsRoleScientific PublicationSelection for TreatmentsSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingStressStructureSusceptibilitySynapsesSynapticThalamic structureThalamusTimeTissuesTrans-Synaptic DegenerationTransneuronal Retrograde DegenerationsVenousVisualVisual PathwaysZeugmatographyagesbiological signal transductionblood flow in brainbrain MR imagingbrain MRIbrain atrophybrain blood circulationbrain blood flowbrain magnetic resonance imagingbrain visualizationcerebralcerebral MR imagingcerebral MRIcerebral atrophycerebral blood flowcerebral circulationcerebral magnetic resonance imagingcerebrocirculationcerebrovascular blood flowclinical relevanceclinically relevantcohortcortical atrophydMRIdemyelinatedensitydevelopmentaldiffusion tensor imagingdisabilitydisease durationdisease lengthdisease severitygangliocyteganglion cellgitter cellgray matterillness lengthimagingimaging approachimaging based approachimmune cell infiltrateimprovedindividualized careindividualized patient careindividualized therapeuticinsightinsular sclerosislymph cellmaculamacularmagneticmeasurable outcomemesogliametabolic ratemicroglial cellmicrogliocytemultiple sclerosis patientmultiple sclerosis therapymultiple sclerosis treatmentnatural agingnerve cementneural degenerationneural dysfunctionneurodegenerationneurodegenerativeneurological degenerationneuronalneuronal degenerationneuroprotectionneuroprotectivenormal agingnormative agingnoveloptical Doppler tomographyoptical coherence Doppler tomographyoptical coherence tomography angiographyoutcome measurementpatients with MSpatients with multiple sclerosispeople with Multiple sclerosisperivascular glial cellpersonalized carepersonalized patient carepersonalized therapeuticpredictive toolspreservationracialracial backgroundracial originre-myelinatere-myelinationrecruitremyelinateremyelinationresolutionsretina blood vessel structureretinal imagingretinal vascular networkretinal vascular structureretinal vasculatureselection of treatmentsexsocial rolesubstantia griseasynapsethalamictherapy selectiontooltractographytraffickingtreatment selectionvascular
Description preview
Project Summary/Abstract
One of the challenges facing treatment of people with multiple sclerosis (pwMS) is determining
their likelihood of progression. This is critical since it influences risk-benefit and therapy
selection. We are validating objective state-of-the-art MRI methods (e.g. separation of myelin vs
iron-based signal [chi [ꭓ]…
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