grant
Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder
NIHUS FederalResearch GrantFY2026AbstinenceAdanonAddressAdmissionAdmission activityAgonistAlthoseAmbulatory MonitoringAnhedoniaBehavioralBindingBrainBrain Nervous SystemBrain imagingChronicClinicalClinical ResearchClinical StudyDSM-5DSM-VDSM5DarknessDataDevelopmentDiagnosticDiagnostic and Statistical Manual of Mental Disorders, 5th editionDiagnostic and Statistical Manual of Mental Disorders-VDolophineDown-RegulationDrugsEncephalonEpidemicFamilyFrequenciesFunctional MRIFunctional Magnetic Resonance ImagingFutureGoalsHumanImageIndividualIndividual DifferencesInpatientsLinkLiteratureMapsMeasuresMediatingMedicationMethadoneMethadoseModelingModern ManMolecular InteractionNIDANational Institute of Drug AbuseNational Institute on Drug AbuseNational Institutes of HealthNegative ReinforcementsOpiate ReceptorsOpiate agonistOpiate receptor agonistOpiatesOpioidOpioid ReceptorOpioid agonistOpioid receptor agonistOut-patientsOutpatient MonitoringOutpatientsPETPET ScanPET imagingPETSCANPETTParticipantPatient Self-ReportPatternPersonsPharmaceutical PreparationsPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPropertyPublic HealthRad.-PETReceptor ProteinRecoveryRelapseResearchRewardsRoleSamplingScanningSelf-ReportSideSystemTechniquesTestingTherapeuticTimeToxicologyTracerUnited States National Institutes of HealthUrineWorkaddictionaddictive disorderbrain visualizationclinical predictorsclinical relevanceclinically relevantdevelopmentaldrug/agentdysphoriaexperiencefMRIhuman datahuman imaginghuman subjectimagingimaging studyin vivoinfancyinfantileinsightkappa opiatekappa opioidkappa opioid receptorsmu receptorsmulti-modalitymultimodalitynegative affectnegative affectivityneuralneural circuitneural circuitryneural correlateneural patterningneurochemicalneurochemistryneurocircuitrynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetopiate consumptionopiate crisisopiate drug useopiate intakeopiate useopiate use disorderopioid consumptionopioid crisisopioid drug useopioid epidemicopioid intakeopioid useopioid use disorderpharmacologicpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpre-clinical researchpreclinicalpreclinical researchradiolabelradiolabelsradiotracerreceptorreceptor functionresponsesecondary analysissocial rolestandard of caresynaptic circuitsynaptic circuitrytherapeutic agent developmenttherapeutic developmenttranslational applicationsκ opiateκ opioidκ opioid receptorsκ-ORκORμ receptors
Description preview
Abstract
Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder
The opioid epidemic is one of the worse U.S. public health crises of the past three decades [1]. In response to
this epidemic, the National Institute of Health launched a multi-pronged initiative a goal to develop new
medications for the treatment of Opioid Use…
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