grant
Illuminating the gene regulatory strategies underlying yeast meiosis and beyond
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Jan 2020Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2025Budding YeastCase StudyCell BodyCell ComponentsCell FunctionCell PhysiologyCell ProcessCell StructureCellsCellular FunctionCellular PhysiologyCellular ProcessCellular RegulationCellular StructuresCodeCoding SystemCodonCodon NucleotidesComplexCuesData SetDevelopmentEndomycetalesEnvironmentEukaryotaEukaryoteEventFecundabilityFecundityFertilityFundingGametesGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenerationsGenesGenomic approachGerm CellsGerm-Line CellsGoalsHealthHumanIsoformsKnowledgeMachine LearningMammalian CellMediatingMeiosisMessenger RNAModelingModern ManMolecularNon-sense Mediated DecayNonsense-Mediated DecayOrganismPrevalenceProcessProductionProtein IsoformsProteinsRegulationReproductive CellsRoleSaccharomycetalesSex CellSexual ReproductionStructureSubcellular ProcessSystemTranscriptTranslatingWorkYeastscase reportcell growth regulationdata integrationdevelopmentalexpectationgenome annotationgenomic effortgenomic strategyglobal gene expressionglobal transcription profilein vivoinitial cellliving systemmRNAmachine based learningmeioticmemberprecursor cellprogramsprotein complexsexual cellsocial roletranscriptome
Description preview
Abstract. Meiosis is the conserved differentiation program that creates gametes. It fails frequently, with
devastating consequences for human fertility and health. As a cell progress through meiotic differentiation, it
undergoes irreversible changes in cellular structure and function that are largely driven by gene expression
changes. Because the…
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