grant
Illuminating multiplexed RNA dynamics to interrogate splicing in health and disease
Organization GEORGETOWN UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 1 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectAlternate SplicingAlternative RNA SplicingAlternative SplicingBiologic ModelsBiologicalBiological ModelsBody CompositionCancersCell BodyCell FunctionCell NucleusCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelComplexCuesCytoplasmic GranulesDNA mutationDiseaseDisease ManagementDisorderDisorder ManagementFLIM imagingFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyFoundationsFunctional RNAFutureGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenetic ChangeGenetic defectGenetic mutationGoalsHealthHumanImaging DeviceImaging InstrumentImaging ToolIntervening SequencesIntronsInvestigationInvestigatorsJoining ExonsLabelLinkLow Molecular Weight Nuclear RNAMalignant NeoplasmsMalignant TumorMammalian CellMessenger RNAModel SystemModern ManMutationNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNon-Polyadenylated RNANoncoding RNANontranslated RNANucleusOutcomePlayProcessProteinsRNARNA Gene ProductsRNA SplicingReactionRegulationResearchResearch PersonnelResearchersRibonucleic AcidRoleSmall Molecular Weight RNASmall Nuclear RNASpliceosomesSplicingSubcellular ProcessSystemTimeUntranslated RNAVisualizationWorkbiologicenvironmental stressesenvironmental stressorfluorescence life-time imagingfluorescence life-time imaging microscopyfluorescence lifetime imagingfluorescence lifetime imaging microscopygenome mutationgranulehuman diseaseimage-based methodimaging methodimaging modalityinsightinterestmRNAmalignancyneoplasm/cancerneurological diseasenoncodingprogramssnRNAsocial rolespatial and temporalspatial temporalspatiotemporaltooluRNA
Description preview
Ribonucleic acids (RNAs) play key roles in numerous cellular processes. A classic example is alternative
splicing, where the large megadalton spliceosome complex removes intron regions from the pre-messenger
RNA (pre-mRNA) and re-joins the exons to form the mature mRNA in the nucleus. The spliceosome consists
of protein and non-coding RNA…
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