grant
Illuminating Glial Dysfunction in Alzheimer’s Disease with Optical Coherence Tomography
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD modelAD pathologyAD related dementiaADRDAPP-PS1APP/PS1AQP4 proteinAbeta clearanceAdultAdult HumanAgeAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAmentiaAmino AcidsAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β clearanceAmyloid β-PeptideAmyloid β-ProteinAnatomic SitesAnatomic structuresAnatomyAntibodiesAquaporinsAssayAβAβ clearanceBioassayBiological AssayBiologyBlood VesselsBrainBrain Nervous SystemCNS Nervous SystemCNS lymphatic systemCaliforniaCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsCenter for Translational Science ActivitiesCentral Nervous SystemCerebrospinal FluidClinicClinicalClinical SciencesClinical TrialsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDegenerative Neurologic DisordersDementiaDetectionDevelopmentDiagnosisDiagnostic testsDiseaseDisorderDisturbance in cognitionDoppler OCTDysfunctionElementsEncephalonFellowshipFunctional disorderFundingGeneticGenetic PolymorphismGliaGlial CellsGlymphatic impairmentGlymphatic system dysfunctionGlymphatic system impairmentGoalsHealthHumanHydrogen OxideImaging in rodentImpaired cognitionImpairmentIn VitroInstitutionIntercellular FluidInterstitial FluidsInterventionIntracellular Communication and SignalingInvestigatorsIsoformsKO miceKnock-out MiceKnockout MiceKnowledgeKolliker's reticulumLightLinkLocationMeasurementMeasuresMediatingMemory DeficitMemory impairmentMentorsMethodsMiceMice MammalsModelingModern ManMonitorMuller gliaMuller's cellMurineMusMutant Strains MiceMüller cellMüller gliaNational Institutes of HealthNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeuritic PlaquesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologistNeurologyNeuronsNon-neuronal cellNonneuronal cellNull MouseOCT TomographyOcular PathologyOptical Coherence TomographyOsmosisOutcomePETPET ScanPET imagingPETSCANPETTPathogenesisPathologicPathway interactionsPatientsPersonsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiciansPhysiologicPhysiologicalPhysiologyPhysiopathologyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProductionProtein IsoformsProteinsRad.-PETReportingResearchResearch PersonnelResearch ResourcesResearchersResourcesRetinaRodentRodentiaRodents MammalsRoleScientistSenile PlaquesSightSignal TransductionSignal Transduction SystemsSignalingTechniquesTechnologyTestingTrainingTranslatingUnited States National Institutes of HealthUniversitiesVisionVisual ReceptorWaterWater Channel ProteinsWater Movementsa beta peptidea-beta peptide clearanceabetaabeta accumulationabeta aggregationabeta peptide clearanceadulthoodage associated declineage dependent declineage related declineagesalzheimer modelaminoacidamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid beta clearanceamyloid beta peptide clearanceamyloid beta plaqueamyloid β accumulationamyloid β aggregationamyloid-b plaqueamyloid-b proteinaquaporin 4aβ accumulationaβ aggregationaβ plaquesbeta amyloid fibrilbiological signal transductionbiomarker developmentbrain lymph systembrain lymphatic systemcareercareer developmentcell culturecell culturescerebral spinal fluidcognitive dysfunctioncognitive losscored plaquecostdecline with agedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiagnostic tooldiffuse plaquedisease modeldisorder modelexperiencefluid flowglia lymphatic circuitglia-lymphatic systemglial lymphatic systemglialymphatic circuitglialymphatic networkglialymphatic pathwayglialymphatic systemglymphatic clearance pathwayglymphatic dysfunctionglymphatic pathwayglymphatic systemglymphatic-lymphatic systemglymphaticsimage-based methodimaging methodimaging modalityimaging studies in rodentimaging studies of rodentimprovedinterstitialknock-out animalknockout animalmemory dysfunctionmicroscope imagingmicroscopic imagingmicroscopy imagingmild cognitive disordermild cognitive impairmentmonomermouse modelmouse mutantmurine modelnerve cementneurodegenerative illnessneuronalnew diagnosticsnew markernext generationnext generation diagnosticsnon-alzheimer's associated dementianon-alzheimer's disease associated dementianon-alzheimer's disease dementianon-alzheimer's disease related dementianon-alzheimer's related dementianon-invasive imagingnonalzheimer dementianonalzheimer's disease associated dementianoninvasive imagingnovelnovel biomarkernovel diagnosticsnovel markeroptical Doppler tomographyoptical coherence Doppler tomographyparavascular systempathophysiologypathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepolymorphismpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprimary degenerative dementiarecruitresponseretinal imagingrodent imagingsenile dementia of the Alzheimer typeskillssocial rolesoluble amyloid precursor proteinspinal fluidtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranslation assaytranslation strategytranslation to humanstranslational approachtranslational neurosciencetranslational research centertranslational sciences centertranslational strategyvascularvision sciencevisual functionvisual sciencewastingwater channelwater transporter
Description preview
PROJECT SUMMARY / ABSTRACT
Clearance of amyloid beta (Aβ) is facilitated by glial cells, and impaired Aβ clearance is implicated in the
pathogenesis of Alzheimer’s disease (AD). A non-invasive assay of glial function could translate this knowledge
into improved health outcomes – leading to the development of new diagnostic tools and/or…
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