grant
ILC2s as drivers of lung dysfunction in response to early-life inflammation
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldATAC sequencingATAC-seqATACseqAdoptive TransferAdultAdult HumanAffectAgonistAirway Hyper-responsivenessAllergic asthmaAmnionitidesAssayAssay for Transposase-Accessible Chromatin using sequencingAsthmaAsthma in ChildrenAutomobile DrivingB Cell Differentiation Factor IB blood cellsB cellB cell growth factor 2B cellsB-Cell Growth Factor-IIB-CellsB-LymphocytesB-cellBCGF-IIBCGF2BioassayBiological AssayBiological MarkersBlood EosinophilBlood Precursor CellBody TissuesBronchial AsthmaCell BodyCell Communication and SignalingCell CompartmentationCell CompartmentationsCell FunctionCell PhysiologyCell ProcessCell ShapeCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChildChild YouthChildhood AsthmaChildren (0-21)ChorioamnionitisChronic DiseaseChronic IllnessChronologic Fetal MaturityCord BloodCytotoxic cellDataData SetDevelopmentDown-RegulationDysfunctionEo-CSFEosinophil Differentiation FactorEosinophilic GranulocyteEosinophilic LeukocyteEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExpression SignatureExtrinsic asthmaFOXP3FOXP3 geneFetal AgeForkhead Box P3Functional disorderGene DeletionGene Expression ProfileGene TranscriptionGeneticGenetic TranscriptionGestationGestational AgeGoalsHematopoietic Progenitor CellsHematopoietic stem cellsHistologicHistologicallyHospital AdmissionHospitalizationHumanHuman DevelopmentHyperactivityIL-13IL-5IL13IgA enhancing factorImmuneImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune MarkersImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune infiltratesImmunesImmunityImmunologic DiseasesImmunologic MarkersImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImpairmentInfectionInfection of amniotic cavityInfection of amniotic sac and membranesInflammationInflammatoryInterferon Type IInterleukin 5 PrecursorInterleukin-13Interleukin-5Intracellular Communication and SignalingInvestigationJM2K lymphocyteLifeLinkLungLung Respiratory SystemLymphoid CellMapsMarrow EosinophilMediatingMediatorMiceMice MammalsModelingModern ManMolecularMurineMusNK CellsNatural Killer CellsPathogenesisPathogenicityPatientsPediatric asthmaPhenotypePhysiopathologyPoly I-CPolyinosinic-Polycytidylic AcidPredispositionPregnancyPreventionProductionPublic HealthPublishingPulmonary PathologyRNA ExpressionRegulatory T-LymphocyteResearchRiskRoleSCURFINShapesSignal TransductionSignal Transduction SystemsSignalingStimulusSubcellular ProcessSusceptibilityT cell replacing factorT-Cell Replacing FactorT-CellsT-LymphocyteTLR3TLR3 geneTestingTherapeutic InterventionTissuesToll-Like Receptor 3TrainingTranscriptionTransplantationTregUmbilical Cord BloodViralViral DiseasesVirus DiseasesWorkadulthoodairway hyper-reactivityairway hyperactivityairway hyperreactivityairway hyperresponsivenessairway hypersensitivityassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingasthma preventionatopic asthmabio-markersbiologic markerbiological signal transductionbiomarkerblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcellular targetingchronic disordercytokinedevelopmentaldrivingeosinophilepigeneticallyepigenomicsexperimentexperimental researchexperimental studyexperimentsextrinsic allergic asthmafetalfetal cord bloodgene deletion mutationgene expression patterngene expression signaturehematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellimmune activationimmune cell infiltrateimmune-based biomarkersimmunological biomarkersimmunological markersinnovateinnovationinnovativeintervention therapyintra-amniotic infectionintraamniotic infectionkidslife spanlifespanlung functionlung pathologymolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentmouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathophysiologypoly I:Cpoly ICpoly(I:C)postnatalprenatalprogenitorprogenitor cell fateprogenitor fateprogramspulmonary functionregulatory T-cellsresponsesexsocial rolestem and progenitor cell fatestem cell fatethymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptomicstransplantunbornviral infectionvirus infectionvirus-induced diseaseyoungster
Description preview
Childhood asthma is a leading cause of chronic disease and hospitalization in children. Viral infections within
the first year or two of life are strongly associated with childhood asthma risk, but the immune mechanisms
mediating this association are poorly understood. The long-term goal of this proposal is to define how early-life
inflammation…
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