grant
IL-1R1 in Endothelial-to-Mesenchymal Activation
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 1 Mar 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20253-10CAMCF-IASCVDATP-protein phosphotransferaseAcute myocardial infarctAcute myocardial infarctionAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesArterial Fatty StreakArteriesAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseAtherosclerotic capB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBeta Proprotein Interleukin 1BloodBlood Reticuloendothelial SystemBlood VesselsBlood flowBlood leukocyteBypassCCL2CCL2 geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCXCL8Cardiac DiseasesCardiac DisordersCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCas nuclease technologyCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChemokine, CC Motif, Ligand 2ClinicalClosure by LigationClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisDataDeathDeath RateDevelopmentDietDiseaseDisorderEndothelial CellsEndotheliumFibrous CapGCP1GWA studyGWASGene InactivationGene SilencingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesHPGFHeart DiseasesHeart VascularHepatocyte-Stimulating FactorHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-1IL-1 ReceptorsIL-1 betaIL-1 βIL-1-bIL-1βIL-6IL-8IL1IL1 ReceptorsIL1-BetaIL1-βIL1B ProteinIL1F2IL1βIL6 ProteinIL8IL8 geneIRAKIRAK1IRAK1 geneIRAK4IRAK4 geneImmuneImmune PrecipitationImmune responseImmunesImmunoprecipitationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIn VitroInfectionInflammationInflammatoryInterleukin 1betaInterleukin ActivationInterleukin IInterleukin-1Interleukin-1 Receptor-Associated Kinase 1Interleukin-1 Receptor-Associated Kinase 4Interleukin-1 ReceptorsInterleukin-1 betaInterleukin-1βInterleukin-6Intracellular Communication and SignalingK60KO miceKinase Family GeneKinasesKnock-out MiceKnockout MiceKnowledgeLesionLeukocyte CountLeukocyte NumberLeukocytesLeukocytes Reticuloendothelial SystemLigationLineage TracingLinkLipidsLymphocyte-Stimulating HormoneMCAFMCP-1MCP1MGI-2Macrophage Cell FactorMapsMarrow leukocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMesenchymalMiceMice MammalsModelingModern ManMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMorbidityMorbidity - disease rateMurineMusMyeloid Differentiation-Inducing ProteinMyocardial InfarctMyocardial InfarctionNY-REN-64Null MouseOutcome StudyPathogenesisPatientsPhenotypePhosphotransferase GenePhosphotransferasesPlasmacytoma Growth FactorPlayPreinterleukin 1 BetaProcessProtein KinasePublishingQOL improvementREN64RNA SeqRNA sequencingRNAseqReceptor SignalingResearchRoleRuptureSCYA2SCYB8Scaffolding ProteinSecondary toSeverity of illnessSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSmall Inducible Cytokine A2Subcellular ProcessSudden DeathT Helper FactorTSG-1TestingTherapeuticTherapeutic EffectThickThicknessThrombosisTranscription Factor Proto-OncogeneTranscription factor genesTransfectionTransphosphorylasesWhite Blood Cell CountWhite Blood Cell Count procedureWhite Blood CellsWhite CellWorkatheromatosisatherosclerosis plaqueatherosclerotic coronary diseaseatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic vascular diseaseb-ENAPbiological signal transductioncardiac infarctcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingcirculatory systemclinical relevanceclinically relevantcoronary arterial diseasecoronary attackcoronary infarctcoronary infarctioncytokinedevelopmentaldietsdisease riskdisease severitydisorder riskfeedinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglycogen synthase a kinaseheart attackheart disorderheart infarctheart infarctionhost responsehuman diseasehydroxyalkyl protein kinaseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovements in QOLimprovements in quality of lifein vivoinhibitorinterferon beta 2lymphocyte activating factormortalitymortality ratemortality ratiomouse modelmurine modelmutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionpellepercutaneous coronary interventionphosphorylase b kinase kinaseplaque capplaque lesionplaques in atherosclerosispreventpreventingquality of life improvementrecruitresponsesocial roletherapeutic targetthrombotic diseasethrombotic disordertranscription factortranscriptional silencingtranscriptome sequencingtranscriptomic sequencingtreatment strategyvascularvectorwestern dietwestern-style dietwestern-type dietwhite blood cellwhite blood corpusclewhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY:
Endothelial-to-mesenchymal transition (EndMT) has been detected in atherosclerosis, and the extent of EndMT
observed in the human plaques strongly correlates with the severity of the disease, implying clinical relevance
of EndMT in the pathogenesis of atherosclerosis. Both disturbed blood flow (d-flow) and interleukin-1 signaling…
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