Identifying the correlates of protection against Streptococcus pneumoniae respiratory tract infection using a human challenge model

Challenge:

Despite widespread use of the existing capsular polysaccharide vaccines, in the UK there are still 92,000 admissions and 40,000 deaths per year due to Streptococcus pneumoniae pneumonia in adults. New approaches to prevent S. pneumoniae lung infections are needed, and this is the challenge our proposal addresses.

Context:

Recurrent…