grant
Identifying the core transcriptional regulatory network initiating a tooth program
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Jul 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult DentitionAdult HumanAgingAnimal ModelAnimal Models and Related StudiesAssayBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBirth DefectsCUT&RUNCell BodyCell LineageCellsCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCommunicationCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCoupledDNA Synthesis FactorDefectDentalDevelopmentEctodermEctoderm CellEctodermal CellEctopic ExpressionElderlyEndothelial Cell Growth FactorEnvironmentEpitheliumExperimental DesignsFGFFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorFutureGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGoalsHealthHumanIncisorInferior Maxillary BoneKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLaser ElectromagneticLaser RadiationLasersLeadLifeMandibleMaxillaMesenchymasMesenchymeMiceMice MammalsMicrodissectionModelingModern ManMolecularMorphologyMouth DiseasesMurineMusNatural regenerationNull MouseOralOral Cavity DiseaseOral Cavity DisorderOral DiseaseOral DisorderOrgan failureOutcome StudyPb elementPermanent DentitionPopulationProgram DevelopmentRNA ExpressionRNA SeqRNA sequencingRNAseqRegenerating teethRegenerating toothRegenerationRepressionReptilesReptiliaResearchSHHSHH geneSecondary DentitionSharkSideSignal PathwaySkinSonic HedgehogSpecific qualifier valueSpecificitySpecifiedStem Cell DevelopmentStructureSupernumerary ToothTeeth regenerationTestingTimeTissue RecombinationToothTooth LossTooth regenerationTooth structureTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTraumaUpregulationadulthoodadvanced agecatalystcraniofacialcraniofaciesdevelopmentalexperimentexperimental researchexperimental studyexperimentsgenome scalegenome-widegenomewidegeriatricglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadimprovedin vivomandibularmaxillarymodel of animalmouse modelmouth disordermultiomicsmultiple omicsmurine modeloral cavity epitheliumoral epitheliaoral epitheliumoverexpressoverexpressionpanomicspermanent toothprogenitor cell developmentprogenitor developmentprogramsregenerateregeneration based therapyregeneration therapyregenerative therapeuticsregenerative therapyrepairrepairedscRNA sequencingscRNA-seqsenior citizensingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial and temporalspatial temporalspatiotemporalstem and progenitor cell developmentstem cell approachstem cell based approachstem cell methodstem cell methodologystem cell procedurestem cell techniqueteethtranscription factortranscription regulatory networktranscriptometranscriptome sequencingtranscriptomic sequencing
Description preview
PROJECT SUMMARY: Loss of teeth due to oral disease, trauma, aging or congenital defects is one of the
most common organ failures. The first morphological sign of tooth development is the formation of the dental
lamina (DL). How the DL—the critical structure for initiation of a tooth development program—is specified from
naïve maxillary and…
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