grant
Identifying T cell determinants of heritable Frontotemporal dementia
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AD and related dementiaAD dementiaAD patientsAD related dementiaAD therapyAD treatmentADRDALS patientsAddressAffectAgeAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease patientAlzheimer's disease related dementiaAlzheimer's disease therapyAlzheimer's patientAlzheimer's therapyAlzheimers DementiaAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAmyotrophic Lateral Sclerosis patientsAmyotrophic lateral sclerosis and frontotemporal degenerationAmyotrophic lateral sclerosis and frontotemporal dementiaAnimal ModelAnimal Models and Related StudiesAssayAutoimmune StatusAutoimmunityAutologousBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBiological MarkersBloodBlood Reticuloendothelial SystemBlood SerumC9ORF72CD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCaringCell BodyCell CommunicationCell Communication and SignalingCell DifferentiationCell Differentiation processCell FunctionCell InteractionCell IsolationCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell-to-Cell InteractionCellsCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessCerebrospinal FluidCirculationCodeCoding SystemCryofixationCryopreservationCytoskeletal SystemCytoskeletonCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDNA mutationDataDegenerative Neurologic DisordersDiagnosisDiagnosticDipeptidesDiseaseDisease ProgressionDisorderDysfunctionEmotionalEquilibriumEvaluationExhibitsFOXP3FOXP3 geneFTD dementiaFTD/ALSFTLD/ALSForkhead Box P3Frontal Temporal DementiaFrontotemporal DementiaFrontotemporal Lobar Degeneration/Amyotrophic lateral sclerosisFunctional disorderFutureGI microbiomeGehrig's DiseaseGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenotypeGoalsHeritabilityHumanHuman ChromosomesIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneIndividualInduced DNA AlterationInduced MutationInduced Sequence AlterationInflammationInflammatoryInfusionInfusion proceduresInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17InterleukinsIntestinalIntestinesIntracellular Communication and SignalingJM2KO miceKnock-out MiceKnockout MiceKnowledgeLou Gehrig DiseaseLymphoidMacrophageMiceMice MammalsModern ManMotorMotor CellMotor NeuronsMurineMusMutationMyelogenousMyeloidMφNerve DegenerationNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuron DegenerationNeutrophiliaNon-Polyadenylated RNANull MouseOnset of illnessPathogenesisPathogenicityPathologyPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPenetrancePersonsPhysiopathologyPreventative strategyPrevention strategyPreventive strategyPrimary Senile Degenerative DementiaProductionPrognostic MarkerProteinsQOL improvementRNARNA ExpressionRNA Gene ProductsRNA-Binding ProteinsRegulationRegulatory T-LymphocyteRibonucleic AcidRoleSCURFINSamplingSerumSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSocietiesSubcellular ProcessT cell differentiationT cell responseT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTregUnited StatesVesicleWorkagesamyotrophic lateral sclerosis with frontotemporal dementiaamyotrophic lateral sclerosis/FTLDamyotrophic lateral sclerosis/frontotemporal dementiaamyotrophic lateral sclerosis/ftdbacteria in the gutbacterial communitybalancebalance functionbio-markersbiobankbiologic markerbiological signal transductionbiomarkerbiorepositorybowelcell sortingcellular differentiationcerebral spinal fluidchromosome 9 open reading frame 72cold preservationcold storagecytokinedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia riskdigestive tract microbiomedisease onsetdisease severitydisorder onsetenteric microbiomeexperimentexperimental researchexperimental studyexperimentsfront temporal dementiafrontal lobe dementiafrontotemporal dementia-amyotrophic lateral sclerosisfrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobar dementia amyotrophic lateral sclerosisfrontotemporal lobe degeneration associated with dementiagain of functiongastrointestinal microbiomegene productgenome mutationgut bacteriagut dysbiosisgut microbesgut microbial speciesgut microbiomegut-associated microbiomeimprovements in QOLimprovements in quality of lifeinfusionsinhibitorinsightintestinal biomeintestinal microbesintestinal microbiomeintracellular skeletonloss of functionloss of function mutationmicrobialmicrobiomemodel of animalmotoneuronmouse modelmurine modelmutantmutation carrierneuralneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneurological diseaseneuronal degenerationneuroprotectionneuroprotectivenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathophysiologypathwaypatient living with Alzheimer's diseasepatient oriented outcomespatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADprimary degenerative dementiaprognostic biomarkerprognostic indicatorquality of life improvementreceptor expressionregulatory T-cellsresponserisk factor for dementiarisk for dementiasenile dementia of the Alzheimer typesexsocial rolespinal fluidsystemic inflammationsystemic inflammatory responsetherapeutic targetthymus derived lymphocytetraffickingtranscription factor
Description preview
Project Summary/Abstract
Alzheimer’s disease and the related disorder Frontotemporal dementia (FTD) represent a major financial and
emotional burden to society, but to date no preventative strategies have been developed. While a critical barrier
to improving the quality of life for people suffering from or caring for those with FTD is a lack of…
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