grant
Identifying multidimensional signatures of gastric interoception in functional dyspepsia
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY202621+ years old3-D3-Dimensional3DAbdomenAbsenteeismAdultAdult HumanAffectAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnorexia NervosaAnteriorAnxietyAttentionAwarenessBehavioralBiological MarkersBrainBrain Nervous SystemBrain StemBrainstemCausalityCell Communication and SignalingCell NucleusCell SignalingCentral LobeChronicClinicalCognitiveCommunicationComplexConsciousConsciousnessCoupledCuesDataDecision MakingDimensionsDiseaseDisorderDorsalDysfunctionDyspepsiaEatingEmotionalEncephalonEpigastricEsthesiaEtiologyExhibitsFastingFearFeedbackFoodFood IntakeFrightFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderGastrointestinal DiseasesHealth Care CostsHealth CostsHyperactivityHypersensitivityImpairmentIndigestionIngestionInsulaInsula of ReilInteroceptionInterventionIntracellular Communication and SignalingIsland of ReilLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaintenanceMalnutritionMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModelingMorbidityMotilityNMR ImagingNMR TomographyNerveNerve Impulse TransmissionNerve TransmissionNeuronal TransmissionNuclear Magnetic Resonance ImagingNucleusNutritional DeficiencyPainPainfulPathologyPatient Self-ReportPhenotypePhysiopathologyPrefrontal CortexRestRewardsSelf-ReportSensationSeveritiesSignal TransductionSignal Transduction SystemsSignalingStandardizationStomachSymptomsTestingTrainingUnconsciousUnconscious StateUnconsciousnessUndernutritionUnited StatesVisitWorkZeugmatographyabnormal brain functionadulthoodamygdaloid nuclear complexaxon signalingaxon-glial signalingaxonal signalingbio-markersbiologic markerbiological signal transductionbiomarkerblood oxygen level dependentblood oxygenation level dependentbrain MR imagingbrain MRIbrain dysfunctionbrain impairmentbrain magnetic resonance imagingcausationcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcingulate cortexclinical relevanceclinically relevantconsciousness lossdietary deficiencydisease causationdysfunctional brainearly fullnessearly satiationearly satietyeating cuesfMRIfastedfastsfood cuesfrontal cortexfrontal lobegastricgastrointestinal disorderglia signalingglial signalinggut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghunger cuesingestmalnourishedmultidisciplinarynerve signalingneuralneural patterningneural signalingneuronal signalingneurotransmissionnutrition deficiencynutrition deficiency disordernutritional deficiency disorderpathophysiologyprecision medicineprecision-based medicinerecruitresponsesatiated earlythree dimensionaltrait
Description preview
PROJECT SUMMARY/ABSTRACT
Functional dyspepsia (FD) is common, affecting 12% of adults in the United States with high morbidity (e.g.,
work absenteeism, malnutrition) and healthcare costs. FD symptoms most commonly include early satiation
and epigastric pain, worsened by meal ingestion in the absence of clear structural etiology. Precision medicine…
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