grant
Identifying microscopic vasculature within entorhinal cortex in healthy aging and its proximity to pathology profiles in Alzheimer's disease
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 15 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAD brainAD dementiaAD pathologyAD riskAD risk factorAffectAlgorithmsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's brainAlzheimer's disease brainAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAmentiaAmyloidAmyloid SubstanceAnastomosisAnastomosis - actionAnatomic SitesAnatomic structuresAnatomyArchitectureAtlasesAutopsyBiological MarkersBlood VesselsBlood capillariesBody TissuesBrainBrain Nervous SystemBrain VascularCerebrumClinicalClinical MarkersClinical TrialsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCyclicityDataData SetDementiaDetectionDevelopmentDiseaseDisease ProgressionDisorderDisturbance in cognitionEncephalonEngineering / ArchitectureEntorhinal AreaGlycoprotein GP-2GoalsHeterogeneityHistologicHistologicallyHistologyHistopathologyImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpaired cognitionIndividualInvestigationKnowledgeLabelLamininMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingManualsMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMethodsMicroscopicModelingNIAAANMR ImagingNMR TomographyNational Institute on Alcohol Abuse and AlcoholismNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronsNuclear Magnetic Resonance ImagingOpticsPathogenesisPathologicPathologyPatternPenetrationPerfusionPeriodicityPopulationPrimary Senile Degenerative DementiaRhythmicitySamplingSpecificityStaining methodStainsStructureTAR DNA-binding protein 43TDP-43TDP43TauopathiesTissuesValidationVariantVariationVascularizationWhite Matter HyperintensityWorkZeugmatographyaged brainaging brainalzheimer riskarteriolebio-markersbiologic markerbiomarkerbrain vascular damagebrain vascular healthbrain vascular lesioncapillarycapillary bedcerebralcerebral vascularcerebral vascular damagecerebro-vascularcerebrovascularcerebrovascular damagecerebrovascular healthcerebrovascular lesionclinical biomarkersclinically useful biomarkerscognitive controlcognitive dysfunctioncognitive losscohortdensitydevelopmentalentorhinal cortexfrailtyhealth recordhealthy aginghealthy human aginghigh definitionhigh-resolutionhistologic stainshistological stainshuman tissueimagingimaging in vivoin vivoin vivo imagingmedial temporal areamedial temporal lobemesial temporal areamesial temporal lobemetermicrotubule bound taumicrotubule-bound taunecropsynerve cell deathnerve cell lossneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurofibrillary tangle formationneuroimagingneuroimaging biomarkerneuroimaging markerneurological degenerationneurological imagingneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuropathologic tauneuropathological taunew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopticalp-taup-τphospho-tauphospho-τphosphorylated taupost-translational modification of taupostmortemposttranslational modification of taupre-clinicalpreclinicalprimary degenerative dementiaprotein TDP-43protein TDP43reconstructionresilienceresilientrisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk of developing Alzheimer'ssenile dementia of the Alzheimer typesystemic inflammationsystemic inflammatory responsetangle formationtautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathythree dimensionalvalidationsvascularτ Proteinsτ phosphorylation
Description preview
Neuron death overwhelms the entorhinal cortex (EC) in Alzheimer’s disease (AD). Neuronal death, whether
with or without neurofibrillary tangle formation, is the pathology most strongly correlated with dementia. Poor
cerebrovascular health is a known risk factor in AD, but specific vascular territories within EC is not known. The
problem is that…
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