grant
Identifying mechanisms of immune dysregulation via severe pediatric SARS-CoV-2
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20260-11 years old2019 novel corona virus2019 novel coronavirus2019-nCoV21+ years oldARDS in childrenAb responseAddressAdultAdult HumanAffinityAntibodiesAntibody FormationAntibody ProductionAntigenic DeterminantsAntigensAutoantibodiesAutoantigensAutoimmune DiseasesAutoimmune MechanismAutoimmune ProcessAutologous AntigensAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBacteriophagesBinding DeterminantsBiochemicalBiologicalBloodBlood Reticuloendothelial SystemBody TissuesBrittle Diabetes MellitusCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID associated pneumoniaCOVID crisisCOVID epidemicCOVID induced pneumoniaCOVID pandemicCOVID pneumoniaCOVID related pneumoniaCOVID-19COVID-19 anti-viralCOVID-19 antiviralCOVID-19 associated pneumoniaCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 induced pneumoniaCOVID-19 infectionCOVID-19 pandemicCOVID-19 periodCOVID-19 pneumoniaCOVID-19 public health crisisCOVID-19 related pneumoniaCOVID-19 viral pneumoniaCOVID-19 virusCOVID-19 virus infectionCOVID-19 yearsCOVID19 infectionCOVID19 virusCV-19CaliforniaCaringCell BodyCell Culture SystemCell LineCellLineCellsChildChild YouthChildhoodChildren (0-21)ClinicalClinical Treatment MoabCoV-2CoV2Coronavirus Infectious Disease 2019Critical CareCritical IllnessCritically IllCross ReactionsDiagnosticDiseaseDisorderEnterovirusEpitopesExhibitsExposure toFoundationsFutureGenetics-MutagenesisGoalsGrippeIDDMIFNImmuneImmune PrecipitationImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunoprecipitationIn VitroIndividualInfectionInflammatoryInfluenzaInsulin-Dependent Diabetes MellitusInterferonsJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLaboratoriesLeadLifeLinkLong-term cohortLongitudinal cohortLytotoxicityMHC ReceptorMIS-CMacrophageMajor Histocompatibility Complex ReceptorMapsMeasurementMedicineMentorsMonoclonal AntibodiesMultiorgan Inflammatory Syndrome in ChildrenMultisystem Inflammatory Syndrome in ChildrenMutagenesisMutagenesis Molecular BiologyMφNational Institutes of HealthNatureOrganoidsPathogenicityPathologicPathway interactionsPatient IsolationPatientsPb elementPediatric ARDSPediatric Acute Respiratory DistressPediatric Acute Respiratory Distress SyndromePediatricsPhagesPhenotypePhysiciansPositionPositioning AttributeProgram DevelopmentPropertyProtein FragmentProteinsProteomeResearchSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 anti-viralSARS-CoV-2 antiviralSARS-CoV-2 associated pneumoniaSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 induced pneumoniaSARS-CoV-2 infectionSARS-CoV-2 pandemicSARS-CoV-2 pneumoniaSARS-CoV-2 related pneumoniaSARS-CoV-2 viral pneumoniaSARS-CoV2SARS-CoV2 anti-viralSARS-CoV2 antiviralSARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSan FranciscoScanningScientistSelf-AntigensSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome related corona virus 2Strains Cell LinesSudden-Onset Diabetes MellitusSymptomsSystemT cell responseT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMT8 CellsT8 LymphocytesTechnologyTestingTissuesTrainingTranslatingTranslationsType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited States National Institutes of HealthUniversitiesViralWorkWuhan coronavirusadaptive immune responseadaptive immunityadulthoodantibody biosynthesisautoimmune antibodyautoimmune attackautoimmune conditionautoimmune destructionautoimmune disorderautoimmune pathogenesisautoimmune reactivityautoimmunity diseaseautoreactive antibodyautoreactivitybacterial virusbiologiccareer developmentchild patientscohortcoronavirus disease 2019coronavirus disease 2019 anti-viralcoronavirus disease 2019 antiviralcoronavirus disease 2019 associated pneumoniacoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 induced pneumoniacoronavirus disease 2019 infectioncoronavirus disease 2019 pandemiccoronavirus disease 2019 pneumoniacoronavirus disease 2019 public health crisiscoronavirus disease 2019 related pneumoniacoronavirus disease 2019 viruscoronavirus disease associated pneumoniacoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease induced pneumoniacoronavirus disease pandemiccoronavirus disease pneumoniacoronavirus disease related pneumoniacoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 pneumoniacoronavirus disease-19 viruscoronavirus infectious disease-19cross reactivitycultured cell linecytotoxicitydisease phenotypedrivingexperienceexperimentexperimental researchexperimental studyexperimentsfunctional genomicshCoV19heavy metal Pbheavy metal leadhigh definitionhigh-resolutionhost responsehuman diseaseimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseimproved outcomeinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2innovateinnovationinnovativeinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidslife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2mAbsmonoclonal Absmouse modelmultisystem inflammatory syndrome of childrenmurine modelnCoV2novelpathogenpathogen exposurepathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespediatricpediatric inflammatory multisystem syndromepediatric patientspneumonia due to COVIDpneumonia due to COVID-19pneumonia due to SARS-CoV-2pneumonia due to coronavirus diseasepneumonia due to coronavirus disease 2019pneumonia due to severe acute respiratory syndrome coronavirus 2pneumonia in COVIDpneumonia in COVID-19pneumonia in SARS-CoV-2pneumonia in coronavirus diseasepneumonia in coronavirus disease 2019pneumonia in severe acute respiratory syndrome coronavirus 2professorresponseself reactive antibodyserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 anti-viralsevere acute respiratory syndrome coronavirus 2 antiviralsevere acute respiratory syndrome coronavirus 2 associated pneumoniasevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 induced pneumoniasevere acute respiratory syndrome coronavirus 2 pneumoniasevere acute respiratory syndrome coronavirus 2 related pneumoniasevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2skillssystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetimelinetranslationtype I diabetestype one diabetesyoungster
Description preview
Project Summary/Abstract
This proposal presents a five year research career development program focused on the mechanisms by
which a dysregulated adaptive immune response to SARS-CoV-2 infection leads particular children to become
critically ill. The candidate is currently a Pediatric Critical Care Medicine (PCCM) clinical fellow at the University…
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