grant
Identifying drug targets in M. abscessus through the application of fluorescent probes
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 9 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AccelerationAcuteAffectAnabolismAntibiotic AgentsAntibiotic DrugsAntibioticsAssayB subtilisB. subtilisBacillus subtilisBacteriaBacterial InfectionsBioassayBiological AssayBiologyBronchiectasisCase StudyCase-Base StudiesCell WallChemicalsChronicClinicalClinical ManagementClinical Trials DesignComplementComplement ProteinsCy5Cystic FibrosisDataDeath RateDevelopmentDiseaseDisorderDrug TargetingDrug resistanceDrugsE coliE. coliEducational process of instructingEnsureEnzyme GeneEnzyme InhibitionEnzymesEscherichia coliFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFluorescent ProbesFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsG24 proteinGelGenus MycobacteriumGoalsGuidelinesInfectionKnowledgeLabelLeadLeftLogicLungLung DiseasesLung Respiratory SystemLung infectionsM abscessusM aviumM tbM tuberculosisM. abscessusM. aviumM. tbM. tuberculosisMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMiceMice MammalsMiscellaneous AntibioticMucoviscidosisMurineMusMycobacterial InfectionMycobacteriumMycobacterium InfectionsMycobacterium abscessusMycobacterium aviumMycobacterium tuberculosisMycobacteroides abscessusNIAIDNational Institute of Allergy and Infectious DiseasePatientsPatternPb elementPenicillin-Binding ProteinsPeptidyl TransferasesPeptidyl TranslocasesPeptidyltransferasePersonsPharmaceutical PreparationsPredispositionProteinsProteomicsPulmonary DiseasesPulmonary DisorderRegimenRegulationResearchResistanceSchemeSurvey InstrumentSurveysSusceptibilityTeachingTestingTranspeptidasesTreatment ProtocolsTreatment RegimenTreatment ScheduleUnited StatesUpdateWorkbacteria infectionbacteria pathogenbacterial diseasebacterial pathogenbeta lactam antibioticbeta lactam hydrolasebeta-Lactamasebeta-Lactamhydrolasebeta-Lactamsbiosynthesiscase reportclinical relevanceclinically relevantcomplementationcrosslinkcyanine dye 5designdesigningdevelopmentaldisease of the lungdisorder of the lungdrug resistantdrug/agentheavy metal Pbheavy metal leadimprovedinnovateinnovationinnovativeinsightlung disordermedical countermeasuremodel organismmortality ratemouse modelmtbmurine modelmycobacterialnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynon-tuberculosis mycobacterianon-tuberculosis mycobacterialnon-tuberculous mycobacterianon-tuberculous mycobacterialnontuberculosis mycobacterialnontuberculous mycobacterianontuberculous mycobacterialnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpathogenic bacteriapulmonarypulmonary infectionsresistance to Drugresistantresistant to Drugresponsesynergismtherapeutically effectiveβ lactam antibioticβ-Lactamaseβ-Lactams
Description preview
Project Summary
In the United States, a person is more likely to be infected by a non-tuberculous mycobacteria (NTM) than
Mycobacterium tuberculosis (Mtb). Most NTM pulmonary infections are caused by one of two species:
Mycobacterium avium or Mycobacterium abscessus (Mab). Of the two, infections with Mab are the most
difficult to cure and,…
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