grant
Identifying deficient memory replay as a potentially treatable mechanism of impaired sleep-dependent memory consolidation in schizophrenia
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 19 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY202521+ years oldAcoustic StimulationAddressAdultAdult HumanAdvisory CommitteesAlgorithmsAmmon HornAnimal ModelAnimal Models and Related StudiesAnimalsAntipsychotic AgentsAntipsychotic DrugsAntipsychoticsAuditory StimulationAutopsyBehaviorBiological MarkersBrainBrain Nervous SystemClinicalClinical TrialsCognitionCognitive deficitsCommunicationConnector NeuronCornu AmmonisCoupledCouplingDataData AnalysesData AnalysisData BasesData SetDatabasesDevelopmentDisablingDrugsDysfunctionEEGElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EncephalonEnsureEpilepsyEpileptic SeizuresEpilepticsEvaluationEventFunctional disorderFutureGoalsGrantHippocampusHumanImpairmentIndividualInpatientsInstructionIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionK01 AwardK01 MechanismK01 ProgramLaboratoriesLearningLiteratureMachine LearningMajor TranquilizersMajor Tranquilizing AgentsMeasurementMediatingMedicationMemoryMemory DeficitMemory impairmentMental disordersMental health disordersMentored Research Scientist Development AwardMentored Training AwardMentorshipMethodologyModern ManNIMHNational Institute of Mental HealthNeuroleptic AgentsNeuroleptic DrugsNeurolepticsNeurophysiology / ElectrophysiologyNeurosciencesNon-Invasive DetectionNoninvasive DetectionOutcomes ResearchParticipantPatientsPharmaceutical PreparationsPhysiologicPhysiologicalPhysiologyPhysiopathologyPlayPsychiatric DiseasePsychiatric DisorderRecoveryResearchResearch ProposalsResearch Scientist Development AwardRestScalpScalp structureSchizophreniaSchizophrenic DisordersSeizure DisorderSleepSleep DeprivationSleep disturbancesStructureTask ForcesTechniquesTestingTimeTrainingTranslatingaberrant sleepabnormal brain functionadulthoodadvisory teamalgorithm trainingarchival dataarchived databio-markersbiologic markerbiomarkerbrain dysfunctionbrain impairmentcognitive defectscognitive neurosciencedata archiveddata basedata interpretationdeficient sleepdementia praecoxdensitydevelopmentaldiagnostic biomarkerdiagnostic markerdisrupted sleepdisturbed sleepdrug/agentdysfunctional braineffective interventioneffective therapyeffective treatmentelectrophysiologicalepilepsiaepilepsy participantepilepsy patientepilepsy subjectepilepsy volunteerepileptic patientepileptic subjectepileptogenicexperiencefunctional outcomeshippocampalimpaired sleepimprovedimprovement on sleepinadequate sleepinsightinsufficient sleepirregular sleepmachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmemory consolidationmemory dysfunctionmental illnessmodel of animalmouse modelmurine modelnecropsyneural circuitneural circuitryneural controlneural imagingneural regulationneuro-imagingneurocircuitryneuroimagingneurological imagingneuromodulationneuromodulatoryneuronal patterningneuropathologicneuropathologicalneuropathologyneurophysiologicalneurophysiologyneuropsychiatric diseaseneuropsychiatric disorderneuroregulationnew approachesnovelnovel approachesnovel strategiesnovel strategypathophysiologypatients with epilepsypostmortempsychiatric illnesspsychological disorderpsychotic symptomsschizophrenicsleep debtsleep deficiencysleep deficitsleep disruptionsleep dysregulationsleep improvementsleep insufficiencysleep losssleep spindlesleep/wake disruptionsleep/wake disturbancesoundsuccesssynaptic circuitsynaptic circuitrytool
Description preview
Cognitive deficits are the strongest predictor of functional outcome in in schizophrenia (SZ). Even after psychotic
symptoms have been controlled with antipsychotic drugs, debilitating cognitive deficits persist. The lack of a
mechanistic understanding of cognitive deficits is a major impediment to developing effective treatments to
improve…
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