grant
Identifying Collaborating Factors Driving DDX41 Mutant Pathology in MDS
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Feb 2026Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY202621+ years oldAML - Acute Myeloid LeukemiaATP phosphohydrolaseATPaseAbnormal CellAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAdenosine TriphosphataseAdultAdult HumanAffectAgeAgingAllelesAllelic LossAllelomorphsAnemiaAssayAutomobile DrivingBar CodesBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBiologyBloodBlood CellsBlood Precursor CellBlood Reticuloendothelial SystemBone marrow failureBrachydanio rerioCell BodyCell Communication and SignalingCell CycleCell Division CycleCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCharacteristicsClonalityCollaborationsCoupledDNA HelicasesDNA Unwinding ProteinsDNA mutationDNA unwinding enzymeDanio rerioDifferentiation in cell cultureDiseaseDisorderDysfunctionDysmyelopoietic SyndromesEarly DiagnosisEarly InterventionEnvironmentErythropoiesisEventEvolutionFrequenciesFunctional disorderGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGerm LinesGerm-Line MutationHSC differentiationHematologic Body SystemHematologic Organ SystemHematopoiesisHematopoieticHematopoietic Body SystemHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic SystemHematopoietic stem cellsHereditaryHereditary MutationHeterozygoteHomeo BoxesHomeo DomainHomeoboxHumanHuman ChromosomesIn vitro cell differentiationIndividualInflammationInflammatoryInheritedInherited bone marrow failureIntracellular Communication and SignalingLineage TracingLinkLoss of HeterozygosityMediatingModalityModelingModern ManMolecularMutateMutationMyelodysplastic DiseaseMyelodysplastic SyndromesMyelogenousMyeloidMyeloid DiseaseMyeloid MalignancyMyeloid NeoplasmMyeloid TumorMyeloproliferative DisordersMyeloproliferative TumorsMyeloproliferative diseaseOutputPathologyPathway interactionsPatientsPeripheral Blood CellPhysiopathologyPilot ProjectsProcessProductionProgenitor CellsPrognosisProliferatingPublic HealthRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsRegulationResearchRiskShapesSignal TransductionSignal Transduction SystemsSignalingSmoldering LeukemiaSomatic MutationSubcellular ProcessSymptomsTestingTherapeuticTranscription Factor Proto-OncogeneTranscription factor genesTransplantationUnited StatesZebra DanioZebra FishZebrafishacute granulocytic leukemiaacute myeloid leukemiaadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagedagesbarcodebiological signal transductionbiomarker discoverybiomarker identificationblood cell formationblood cell progenitorblood progenitorblood stem cellblood-forming stem cellbone marrow failure syndromecell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell stresscellular lineage mappingcellular lineage trackingcytopeniadifferentiation in culturedifferentiation in vitrodrivingearly detectionearly onseterythroid developmentexhaustionfitnessgene signaturesgenetic signaturegenome mutationgerm-line defectgermline varianthelicasehematopoietic differentiationhematopoietic progenitorhematopoietic progenitor cell differentiationhematopoietic progenitor differentiationhematopoietic stem cell differentiationhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellheterozygosityhiPSChigh riskhomeodomainhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsidentification of biomarkersidentification of new biomarkersin vitro cellular differentiationin vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinherited disease of bone marrow failureinsightlater in lifelater lifeloss of function mutationmarker identificationmutantmyelodysplasiamyeloproliferative neoplasmolder adultolder adulthoodpathophysiologypathwaypilot studypre-clinicalpreclinicalpressureprogenitorprogenitor cell expansionprogenitor cell functionprogenitor cell proliferationprogenitor expansionprogenitor functionprogenitor proliferationprogression riskresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsomatic variantstemstem and progenitor cell expansionstem and progenitor cell functionstem and progenitor cell proliferationstem and progenitor functionstem cell expansionstem cell functionstem cell proliferationstem cellssynergismtranscription factortransplant
Description preview
As we age, the efficiency of the hematopoietic system declines resulting in bone marrow failure symptoms in
some individuals. Myelodysplastic syndromes (MDS) are disorders primarily affecting older adults and impact
around 10,000 individuals annually in the United States. MDS arises due to dysfunction in hematopoietic stem
and progenitor cells…
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