grant
Identifying and Targeting 3D Regulatory Nodes that Maintain Glioblastoma Programs
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAddressAdultAdult HumanArchitectureAssayBasal Transcription FactorBasal transcription factor genesBehaviorBindingBioassayBiological AssayBiologyBrain NeoplasiaBrain NeoplasmsBrain TumorsCancersCell BodyCell NucleusCellsChromatinClinicalCoinCommunicationComplexComputational BiologyComputer AnalysisComputer ModelsComputerized ModelsDNADNA AlterationDNA Sequence AlterationDataData SetDeoxyribonucleic AcidDrug resistanceElementsEndowmentEngineeringEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsFunctional RNAFutureGene ExpressionGene TranscriptionGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic AlterationGenetic DiversityGenetic TranscriptionGenetic VariationGenomeGenomicsGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGlioblastoma stem like cancer cellGliomaGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHeterogeneityIntratumoral heterogeneityKnowledgeLinkLogicMalignant NeoplasmsMalignant TumorMolecularMolecular InteractionMultiomic DataNeighborhoodsNetwork AnalysisNetwork-basedNeural Stem CellNeuroglial NeoplasmNeuroglial TumorNoncoding RNANontranslated RNANuclearNucleusOncogenicOutcomePathway AnalysisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePrimary Brain NeoplasmsPrimary Brain TumorsProcessPropertyProteinsProteomicsRNA ExpressionRecurrenceRecurrentRegulationResistanceResolutionSamplingSequence AlterationSpecificityStressStructureTechnologyTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesUntranslated RNAWorkadulthoodallelic variantcancer genomicscell typecofactorcomputational analysescomputational analysiscomputational modelingcomputational modelscomputer analysescomputer based modelscomputer biologycomputerized modelingdrug resistanteffective therapyeffective treatmentepigenetic gene silencingepigenetic silencingepigeneticallyexperimentexperimental researchexperimental studyexperimentsexpression subtypesfitnessgene networkgenetic variantgenomic alterationgenomic variantglial-derived tumorglioblastoma cancer stem cellglioblastoma multiformeglioblastoma progenitorglioblastoma stem cellglioblastoma stem like cellglioma cancer stem cellglioma cancer stem like cellglioma progenitorglioma stem cellsglioma stem like cellheterogeneity in tumorsin vivoinsightintra-tumoral heterogeneityintratumor heterogeneitymalignancymolecular sub-typesmolecular subsetsmolecular subtypesmultiple omic dataneoplasm/cancernerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuroglia neoplasmneuroglia tumorneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynoncodingnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoncogenomicspathwaypatient oriented outcomesprogenitor and neural stem cellsprogramsproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialpromoterpromotorresistance to Drugresistance to therapyresistantresistant to Drugresistant to therapyresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspongioblastoma multiformestructural mutationstructural variantstructural variationtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapeutic targettherapy resistantthree dimensionaltooltranscription factortranscriptomicstreatment resistancetumortumor heterogeneitytumorigenictumors in the brain
Description preview
PROJECT SUMMARY
Glioblastoma (GBM) is a highly aggressive and incurable brain tumor. The inter-patient and intra-tumoral
heterogeneity of GBM, resulting from genetic alterations and epigenetic plasticity, poses a major challenge in its
treatment. GBM IDH-wt tumors are composed by different proportions of transcriptionally defined cell states,…
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