grant
Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 4 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAccelerationAccountingAddressAlgorithmsAutoimmune DiseasesAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBehaviorBenchmarkingBest Practice AnalysisBindingBody TissuesCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromosome MappingClinical TreatmentComplexDNADataDedicationsDeoxyribonucleic AcidDiseaseDisorderDistalDrug TargetingERK 1ERK1ERK1 KinaseEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquityEuropeanExtracellular Signal-Regulated Kinase 1Functional RNAGWA studyGWASGene Action RegulationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene LocalizationGene MappingGene Mapping GeneticsGene RegulationGene Regulation ProcessGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic DiversityGenetic ModelsGenetic VariationGenotypeGerm LinesHeritabilityIndividualInvestmentsLinear RegressionsLinkLinkage MappingMAP Kinase 3MAPK3MAPK3 Mitogen-Activated Protein KinaseMAPK3 geneMapsMeasuresMediatingMethodologyMethodsMinorityMissionMitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase 3 GeneModelingMolecular InteractionNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocyteNeuronsNoncoding RNANontranslated RNANucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesP44ERK1PSTkinase p44mpkPersonsPhenotypePopulationPredictive ValueProliferatingPublishingQTLQuantitative Trait LociRNA SplicingRegulationRegulatory ElementRegulatory RegionsResearchResearch DesignRiskSample SizeSchizophreniaSchizophrenic DisordersSplicingStudy TypeSubcellular ProcessTechniquesTimeTissuesTotal Human and Non-Human Gene MappingTranscript Expression AnalysesTranscript Expression AnalysisTranscription Factor Proto-OncogeneTranscription factor genesUnited States National Institutes of HealthUntranslated RNAVariantVariationWorkallelic variantanalyze gene expressionautoimmune conditionautoimmune disorderautoimmunity diseasebenchmarkcandidate biomarkercandidate markercausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typeclinical interventionclinical relevanceclinical therapyclinically relevantcohortcomputer based predictiondementia praecoxdrivingepigeneticallyfeature selectiongene expression analysisgene expression assaygene locusgenetic analysisgenetic associationgenetic locusgenetic mappinggenetic regulatory elementgenetic variantgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic locationgenomic locusgenomic variantglobal gene expressionglobal transcription profilehigh dimensionalityhuman diseaseimprovedinnovateinnovationinnovativeinsightneuronalnoncodingnovelp44 MAPKpolygenetic risk scorespolygenic risk scorepredictive modelingscRNA sequencingscRNA-seqschizophrenicsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstatisticsstudy designtherapeutic agent developmenttherapeutic developmentthree dimensionaltooltraittranscription factortranscriptional profilingtranscriptometranscriptomicstrial regimentrial treatmentwhole genome association analysiswhole genome association study
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Summary/Abstract
Genome-wide association studies (GWAS) have associated hundreds of thousands of genetic variants with
human disease and complex traits. 90% of associated variants reside in noncoding sequences that can
enhance or suppress gene expression levels. While GWAS does not reveal the target genes of associated
variants, extraordinary…
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