grant
Identification of the untranslated sequence elements and virus-host interactions that modulate flavivirus host-specificity
Organization IOWA STATE UNIVERSITYLocation AMES, UNITED STATESPosted 24 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20253' Untranslated Regions3'UTR5' Untranslated Regions5'UTRApplications GrantsArthropodaArthropodsBindingBinding ProteinsBiotinBiotinylationBreakbone Fever VirusCapsid ProteinsCell BodyCell Culture TechniquesCellsChimeraChimera organismCoat ProteinsComplexCulicidaeDENVDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDengue VirusDengue fever virusDetectionDiseaseDisorderEgypt 101 virusElementsFlavivirusFundingGenesGeneticGenetic DeterminismGenomeGenomicsGoalsGrant ProposalsGroup B ArbovirusHumanImmune PrecipitationImmunoprecipitationInsectaInsectsInsects InvertebratesIntervention StrategiesIxodidaJapanese B Encephalitis VirusJapanese encephalitis virusLC/MSLabelLigand Binding ProteinLigand Binding Protein GeneMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingModern ManMolecularMolecular InteractionMosquito ControlMosquitoesNon-Polyadenylated RNAOrthoflavivirusPhenotypePhylogenetic AnalysisPhylogeneticsPost-Transcriptional Gene SilencingProtein BindingProteinsPublic HealthRNARNA Gene ProductsRNA InterferenceRNA PolymerasesRNA SeqRNA SilencingRNA and protein interactionRNA sequencingRNA-Binding ProteinsRNA-Protein InteractionRNAiRNAseqRibonucleic AcidSequence-Specific Posttranscriptional Gene SilencingSerotypingSpecificityStrepavidinStreptavidinStructureTechniquesTicksTransfectionTransmissionTropismUTRsUntranslated RegionsVertebrate AnimalsVertebratesViralViral Coat ProteinsViral GenomeViral Outer Coat ProteinVirusVirus ReplicationVitamin HWNVWest Nile virusYellow fever virusZIKVZika Virusbound proteincell culturecell cultureschimerascoenzyme Rdesigndesigningexperimentexperimental researchexperimental studyexperimentsgenetic determinanthelicasehuman pathogeninsightinterestknock-downknockdownliquid chromatography mass spectrometrymRNA Leader Sequencesmosquito-bornemosquitobornenoveloverexpressoverexpressionprotein crosslinkstemtranscriptome sequencingtranscriptomic sequencingtransmission processvertebrataviral RNAviral multiplicationviral replicationvirus RNAvirus genomevirus host interactionvirus multiplicationzikav
Description preview
Many flaviviruses are adapted to dual-host transmission and maintained in cycles between hematophagous arthropods (i.e. mosquitoes and ticks) and vertebrates. An example of mosquito-borne flavivirus (MBFV) is Zika virus (ZIKV), which is a human pathogen of global concern. Other flaviviruses, such as Long Pine Key virus (LPKV), replicate in…
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