grant
Identification of Immune Activation DNA inside Cells
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 6 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AddressAffinityAicardi Goutieres syndromeArchitectureAutoimmuneAutoimmune DiseasesBasal Transcription FactorBasal transcription factor genesBindingBiochemicalCREE ENCEPHALITISCancersCatalysisCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular injuryCellular modelChIP SequencingChIP-seqChIPseqChemicalsChromatinChronicComplexCrosslinkerCyclic GMPCyclicityDNADNA BindingDNA Binding InteractionDNA CrosslinkingDNA boundDNA-Binding ProteinsDNA-protein crosslinkDataDeoxyribonucleic AcidDiagnosisDinucleoside PhosphatesDiseaseDisorderDouble-Stranded DNADrug TargetingEmbryoEmbryonicEncephalopathy with intracranial calcification and chronic lymphocytosis of cerebrospinal fluidEncephalopathy, familial infantile, with calcification of basal ganglia and chronic cerebrospinal fluid lymphocytosisEngineering / ArchitectureEnsureFibroblastsFormaldehydeFormic AldehydeGTPGene ActivationGeneral Transcription Factor GeneGeneral Transcription FactorsGenomic DNAGuanosine Cyclic MonophosphateGuanosine TriphosphateImmuneImmune Cell ActivationImmune responseImmunesImmunologic StimulationImmunological StimulationImmunostimulationIn VitroIn vivo analysisInfectionInflammagingInflammationInflammatoryInnate Immune ResponseIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceL-LysineLengthLigandsLupus Erythematosus DisseminatusLysineMalignant NeoplasmsMalignant TumorMediatingMethodsMethyl AldehydeModelingMolecularMolecular InteractionMolecular Tumor SuppressionNGS MethodNGS systemNatureNucleosomesNull MouseOxomethanePathologicPathway interactionsPeriodicityPhysiologicPhysiologicalPlayProteinsProtocolProtocols documentationRecoveryReproducibilityRhythmicityRoleSLESideSignal TransductionSignal Transduction SystemsSignalingSourceSpecificityStimulator of Interferon GenesStructureSubcellular ProcessSystemSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTechnologyTherapeuticTranscription Factor Proto-OncogeneTranscription factor genesTumor SuppressionWorkage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentage-related inflammationaging associated diseaseaging associated disordersaging associated inflammationaging related diseaseaging related disordersautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcGMPcell damagecell injurycell stresscellular damagechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcrosslinkcyclic GMP-AMP synthase/STINGdamage to cellsdimerdinucleotidedisease associated with agingdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdisseminated lupus erythematosusds-DNAdsDNAgDNAgenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationhost responsehuman diseaseimmune activationimmune system responseimmunoresponsein vivoin vivo evaluationin vivo testinginflamm-ageinginflamm-aginginflammation associated with aginginjury to cellsinnovateinnovationinnovativeinsightmalignancymicrocephaly-chorioretinopathy syndromeneoplasm/cancernew diagnosticsnew technologynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext gen sequencingnext generation diagnosticsnext generation sequencingnextgen sequencingnovelnovel diagnosticsnovel technologiesnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpathwayprotein crosslinkpseudotoxoplasmosis syndromesenescencesenescentsensorsmall moleculesocial rolesystemic lupus erythematosistherapeutic agent developmenttherapeutic developmenttooltranscription factor
Description preview
Identification of immune activation DNA inside cells
Cyclic GMP-AMP synthase (cGAS) is a key sensor of cytosolic double-stranded DNA (dsDNA) that
activates the STimulator of INterferon Genes (STING) pathway, triggering immune responses against
infections and cellular damage. While cGAS plays a protective role in pathogen defense and tumor…
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