grant
Identification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldATAC sequencingATAC-seqATACseqAdultAdult HumanAffectAmacrine CellsAssay for Transposase-Accessible Chromatin using sequencingBasal Transcription FactorBasal transcription factor genesBlindnessCell BodyCell Communication and SignalingCell Cycle ProgressionCell SignalingCell TherapyCellsChromatinCompetenceCone PhotoreceptorsDevelopmentDevelopmental CourseDiseaseDisorderElectroporationFamilyGene Down-RegulationGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGlaucomaGliaGlial CellsHistologicHistologicallyIntracellular Communication and SignalingKIAA1439Kolliker's reticulumMacular degenerationMacular degenerative diseaseMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMuller gliaMuller's cellMüller cellMüller gliaNFIANFIA geneNerve CellsNerve UnitNeural CellNeurocyteNeuroepithelial CellsNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellNuclear Factor I/APathway interactionsPatternPhenotypePredictive FactorProcessProgenitor CellsProliferatingReceptor ProteinRetinaRetinal ConeRetinal Ganglion CellsRodRoleSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedStem Cell likeTechniquesTestingTimeTranscription Factor NFIATranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesViraladulthoodassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductioncell based interventioncell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular therapeuticcellular therapycone cellconformationconformationalconformational stateconformationallyconformationsconstitutive expressionconstitutive gene expressiondevelopmentaldirected differentiationelectroporative deliverygain of functiongene electrotransfergene functiongene regulatory networkgene repressionglaucomatoushorizontal cellimprovedin vivoloss of functionmultiomicsmultiple omicsmutantnerve cementneurogenesisneuronalnotchnotch proteinnotch receptorsoverexpressoverexpressionpanomicspathwayprogenitorprogenitor capacityprogenitor cell likeprogenitor-likeprogramsreceptorrestore sightrestore visionretinal ganglionretinal progenitorretinal progenitor cellretinal stem cellscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsight restorationsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolestem cell characteristicsstem cellsstem-likestemnesstranscription factortranscription regulatory networkvision lossvision restorationvisual loss
Description preview
Project Summary:
Over the course of developmental neurogenesis, retinal progenitor cells show progressive changes in
their ability to generate specific cell types, and become progressively more likely to undergo both neurogenic
and terminal divisions. Both intrinsic and extrinsic mechanism control these processes, which are collectively
referred…
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