grant

Identification of Brain Circuits Underlying Fear and Panic

Organization IOWA CITY VA MEDICAL CENTERLocation IOWA CITY, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
VANIHUS FederalResearch GrantFY2026AccelerationActive Follow-upAddressAffectAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnimal BehaviorAnimal TestingAnimalsAsphyxiaBackBehaviorBehavior ControlBehavioralBehavioral ManipulationBehavioral ParadigmBrainBrain Nervous SystemBrain regionCO2CaM KIICaM PK IICaM kinase IICaMKIICarbon DioxideCarbonic AnhydrideCausalityCell Communication and SignalingCell SignalingChronicCitiesClinicalCommunicationComplexComprehensive Health CareConsultCustomDataDedicationsDevelopmentDistressDoctor of PhilosophyDorsalDorsumElectrodesEmotionalEmotionsEncephalonEnsureEtiologyExhibitsExposure toFearFoundationsFreezingFrightFutureGoalsHalorhodopsin ChromoproteinHalorhodopsinsHumanHuman ResourcesImplantIndividualInhalationInhalingInternal MedicineInterventionIntracellular Communication and SignalingIowaKnowledgeLeadLinkManpowerMapsMeasuresMedical centerMental disordersMental health disordersMentorsMentorshipMesencephalic Central GrayMethodsMiceMice MammalsMidbrain Central GrayModalityModelingModern ManMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeurosciences ResearchOdorsOpticsOrganismOutcomePTSDPanicPanic DisorderPathologicPatientsPb elementPeriaqueductal GrayPersonsPh.D.PhDPhysiciansPhysiologicPhysiologicalPhysiologyPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrincipal InvestigatorPsychiatric DiseasePsychiatric DisorderPsychiatric therapeutic procedurePsychiatryResearch TechnicsResearch TechniquesRespirationSafetyScientistServicesSignal TransductionSignal Transduction SystemsSignalingSiteStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStimulusStressSuffocationSuicideTechniquesTimeTrainingTranslatingTranslationsVeteransVirusWorkactive followupamygdaloid nuclear complexannulus of the aqueductasphyxiationawakeaxon signalingaxon-glial signalingaxonal signalingbehavior predictionbehavioral controlbehavioral predictionbiological signal transductionbrain controlcalcium-dependent CaM kinase IIcalmodulin-dependent protein kinase IIcareercareer developmentcausationclinical careco-morbidco-morbiditycomorbiditycomprehensive careconsultscustomsdevelopmentaldisabilitydisease causationfallsfatal attemptfatal suicidefightingfollow upfollow-upfollowed upfollowupfoxesglia signalingglial signalinggraduate studentheavy metal Pbheavy metal leadhuman subjectinsightintent to dieintervention refinementliving systemmaladaptive behaviormental illnessmidbrain central gray substancemilitary veteranmodel organismnerve signalingneuralneural controlneural mechanismneural regulationneural signalingneuromechanismneuromodulationneuromodulatoryneuronalneuronal signalingneurophysiologicalneurophysiologyneuroregulationneurosurgeryneurotransmissionnew diagnosticsnext generation diagnosticsnovelnovel diagnosticsopticaloptogeneticspanic anxiety syndromeperiaqueductal gray matterpersonnelpost-trauma stress disorderpostoperative recoveryposttrauma stress disorderpromoterpromotorpsychiatric carepsychiatric illnesspsychiatric inpatientpsychiatric therapypsychiatric treatmentpsychological disorderrecovery after surgeryrecovery following surgeryrespiratory mechanismresponsesocial defeatspatial and temporalspatial temporalspatiotemporalstatistical analysisstressorsuicidestemporal measurementtemporal resolutiontherapeutic targettime measurementtooltranslationtraumatic neurosisveteran population
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Objective: The objective of this proposal is to train Dr. Aubrey Chan, MD/PhD, dual-boarded in internal
medicine and psychiatry, to become an independent VA physician-scientist. He will be mentored in state-of-

the-art neuroscience research techniques in recording neural signals by his mentors Drs. Rainbo Hultman and

Nandakumar Narayanan, and he…

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