grant
Identification and elimination of antigen-specific expanded clones
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AIDS VirusAbscissionAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAfter CareAfter-TreatmentAftercareAnti-Retroviral AgentsAntigenic DeterminantsAntigensAnzataxAsotaxAssayBinding DeterminantsBioassayBiological AssayBlood PlasmaBristaxolCBDCACD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCMVCarboplatinCarboplatinoCell BodyCell DeathCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationCessation of lifeChemotherapy and RadiationChemotherapy and/or radiationCirculatory CollapseClinicalClonal ExpansionClone CellsCytomegalovirusDNADeathDefective HybridsDefective Interfering ParticlesDefective Interfering VirusesDefective VirusesDeoxyribonucleic AcidDiagnosisEpitopesExcisionExtirpationFrequenciesFutureGenesHCMVHIVHIV AntigensHIV individualsHIV infected individualsHIV infected personsHIV peopleHIV positive individualsHIV positive peopleHIV-Associated AntigensHTLV-III AntigensHTLV-III-LAV AntigensHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntigensImmune Cell ActivationIn VitroIncomplete VirusesIndividualInflammationLAV AntigensLAV-HTLV-IIILymphadenopathy-Associated AntigensLymphadenopathy-Associated VirusMalignant Tumor of the LungMalignant neoplasm of lungMeasuresModelingOperative ProceduresOperative Surgical ProceduresPLWHPWHPaclitaxelPaclitaxel (Taxol)ParticipantPatientsPeptidesPlasmaPlasma SerumPraxelPredispositionProcessProliferatingProvirusesPulmonary CancerPulmonary malignant NeoplasmRadiation therapyRadiotherapeuticsRadiotherapyRegimenRemovalResidualResidual stateReticuloendothelial System, Serum, PlasmaSalivary Gland VirusesShockSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSusceptibilityT-Cell ProliferationT-CellsT-LymphocyteT4 CellsT4 LymphocytesTaxolTaxol ATaxol KonzentratTestingTherapeuticVaccinationViralViral AntigensViral BurdenViral LoadViral Load resultViral reservoirViremiaVirusVirus IntegrationVirus reservoirVirus-HIVanti-proliferative agentsanti-proliferative drugsanti-retroviralantiproliferative agentsantiproliferative drugsantiretroviral therapyantiretroviral treatmentchemo-/radio-therapychemo-radiotherapychemo/radiation therapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapychemotherapy and radiotherapycirculatory shockcytomegalovirus groupdesigndesigningdetection limitexperimentexperimental researchexperimental studyexperimentsimmune activationimmunogenindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusintegration sitelung cancernecrocytosisparticlepeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency viruspost treatmentpreventpreventingproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialradiation or chemotherapyradiation treatmentradio-chemo-therapyradio-chemotherapyradiochemotherapyresectionresponseshockssurgerythymus derived lymphocytetreatment with radiationviraemiaviral genome integrationviral integrationviral sepsisvirus antigenvirus genome integrationvirusemia
Description preview
Clonal expansion is a process where latently infected CD4+ T cells proliferate in
response to their cognate antigen. It is thought that this process contributes significantly
to the size of the HIV reservoir and therefore disrupting this mechanism could have a
huge impact on the number of latently infected cells. We observed a significant decline…
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