grant
Hypoxia, tuberculosis, and T cell dysfunction
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AIDSAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAffectAlcoholismAnimal ModelAnimal Models and Related StudiesAntibodiesAutoregulationBacillusBacteriaCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancer TreatmentCancersCell FunctionCell Mediated ImmunologyCell PhysiologyCell ProcessCell surfaceCell-Mediated ImmunityCellular FunctionCellular ImmunityCellular Metabolic ProcessCellular PhysiologyCellular ProcessCessation of lifeChronicClinicalContainmentCoupledDataDeathDevelopmentDiabetes MellitusDiseaseDisorderDrugsDysfunctionEquilibriumFailureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderGeneralized GrowthGoalsGranulomaGranulomatous LesionGrowthHomeostasisHumanHypoxiaHypoxicImmuneImmunesImmunityImmunooncologyImpairmentIn VitroInfectionIntermediary MetabolismInterventionKnowledgeLeadLesionLungLung Respiratory SystemLung TBLung TuberculosisM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalnutritionMapsMediatingMedicationMetabolicMetabolic ProcessesMetabolic stressMetabolismMiceMice MammalsMitochondriaModelingModern ManMouse StrainsMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNutritional DeficiencyOutcomeOxygen DeficiencyPD 1PD-1PD1PathogenesisPatientsPb elementPersonsPharmaceutical PreparationsPhenotypePhysiological HomeostasisPhysiopathologyPrediction of Response to TherapyPredispositionProliferatingPulmonary TBPulmonary TuberculosisReceptor ProteinReceptor SignalingRecrudescencesReporterResistanceResolutionRiskRisk FactorsRoleSmokingSubcellular ProcessSusceptibilityT cell receptor repertoire sequencingT cell receptor sequencingT cell responseT-Cell ActivationT-Cell DevelopmentT-Cell OntogenyT-CellsT-LymphocyteT-Lymphocyte DevelopmentT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTB immunityTB infectionTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTestingTherapeuticTissue GrowthTuberculosisTumor ImmunityTumor-Infiltrating LymphocytesUndernutritionWorkactivate T cellsanti-cancer therapyanti-tumor immunityantitumor immunitybalancebalance functioncancer immunitycancer microenvironmentcancer therapycancer-directed therapycell metabolismcellular metabaolismdevelopmentaldiabetesdietary deficiencydisseminated TBdisseminated tuberculosisdrug/agentexhaustexhaustionexperimentexperimental researchexperimental studyexperimentsflow cytophotometryglobal healthheavy metal Pbheavy metal leadimmune-oncologyimmunity against M. tuberculosisimmunity against Mtbimmunity against Mycobacterium tuberculosisimmunity against TBimmunity against tuberculosisimmunity in tuberculosisimmunity to TBimmunity to tuberculosisimmuno oncologyimmunology oncologyimprovedin vivoinfection due to Mycobacterium tuberculosisinsightmalignancymalnourishedmitochondrialmodel of animalmouse modelmtbmurine modelneoplasm/cancerneovascularizationnutrition deficiencynutrition deficiency disordernutritional deficiency disorderoncoimmunologyontogenypathophysiologypredict therapeutic responsepredict therapy responsepreservationpreventpreventingprogrammed cell death 1programmed cell death protein 1programmed death 1prophylacticreceptorresistantresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2social rolestressorsystemic lupus erythematosus susceptibility 2therapy predictionthymus derived lymphocytetreatment predictiontreatment response predictiontuberculosis immunitytuberculosis infectiontuberculous spondyloarthropathytumortumor microenvironment
Description preview
Abstract. After Mycobacterium tuberculosis (Mtb) infection, 5-10% of people develop clinically evident
tuberculosis (TB), most within two years. This leads to 10 million new cases of TB and 1.5 million deaths each
year. Why immunity fails and permits recrudescence in people that initially control Mtb is unknown. Risk factors
include diabetes,…
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