grant
Hypoxia Core
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 1 Aug 2015Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAirAntioncogene Protein p53Applications GrantsAreaBiochemicalBirthBlood CellsBlood Precursor CellBone MarrowBone Marrow Reticuloendothelial SystemCell BodyCell DeathCell Differentiation InductionCellsCellular Tumor Antigen P53Cellular biologyCirculatory CollapseClinicalCollecting CellCollectionCommunitiesCord BloodCore GrantDataEconomicsEnvironmentEvaluationEventExposure toExpression SignatureGene Expression ProfileGeneral PopulationGeneral PublicGrant ProposalsHSC transplantationHealth BenefitHematologyHematopoiesisHematopoieticHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHematopoietic stem cellsHumanHypoxiaHypoxicImmuneImmunesIn VitroIndianaInvestigatorsJournalsKO miceKnock-out MiceKnockout MiceLearningLifeMagazineMaintenanceMediatorMedicineMiceMice MammalsMitochondriaModern ManMolecularMurineMusNobel PrizeNon-MalignantNull MouseO elementO2 elementOncoprotein p53OrganOxygenOxygen DeficiencyP53ParturitionPeripheral Blood CellPhenotypePhosphoprotein P53Phosphoprotein pp53PhysiologicPhysiologicalPhysiologyPreleukemiaProcessProductionProductivityProtein TP53PublicationsPublishingQualifyingRegulationReportingResearchResearch PersonnelResearch ResourcesResearchersResourcesRoleScientific PublicationScientistServicesShockStimulusStressStromal CellsTP53TP53 geneTRP53Tumor Protein p53Tumor Protein p53 GeneUmbilical Cord BloodUniversitiesWorkadulthoodblood cell formationblood cell progenitorblood progenitorblood stem cellblood stem cell transplantationblood-forming stem cellcell biologycirculatory shockclinical efficacyclinical translationclinically translatablecostcyclophilin Dcyclophilin-40cyclosporin A-SPTPcyclosporin A-sensitive pereability transition porecytokineeconomicfetal cord bloodgene expression patterngene expression signaturehematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitorhematopoietic progenitor cell transplantationhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellimprovedin vivoinsightknockout genemembermitochondrialmitochondrial megachannelmitochondrial permeability transition poremouse modelmurine modelnecrocytosisnonmalignantp53 Antigenp53 Genesp53 Tumor Suppressorperipheral bloodprogenitorprogenitor biologyprogenitor cell biologyprogenitor cell functionprogenitor functionprogramsprotein p53shockssocial rolestemstem and progenitor biologystem and progenitor cell functionstem and progenitor functionstem cell biologystem cell functiontranscriptional profiletranscriptional signaturetranslational opportunitiestranslational potential
Description preview
This revised shared Hypoxia core (HC) is proposed for the Indiana University (IU) Cooperative Center of
Excellence in Hematology (CCEH) to support and enhance research efforts of members of our center, other
CCEH centers, and other qualified US investigators in the area of hematopoiesis and nonmalignant
hematology. Information generated is…
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