grant
Hypothalamic neuronal circuits controlling survival behaviors
Organization NATIONAL INSTITUTE ON DRUG ABUSELocation UNITED STATES
NIHUS FederalResearch GrantFY2025Action PotentialsAffectAnorexiaAnteriorAppetitive BehaviorArcuate NucleusAttentionAttenuatedBehaviorBehavioral AssayBehavioral ParadigmBiologic ModelsBiological ModelsBody Weight decreasedBulimiaBulimia NervosaCalcium-Binding ProteinsCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCollectionDiabetes MellitusDiseaseDisorderDrug abuseEatingEating DisordersElectrophysiologyElectrophysiology (science)Feeding behaviorsFeelingFluorescenceFoodFood IntakeGeneticGlutamatesHuB219HungerHyperphagiaHypothalamic structureHypothalamusIndividualInfundibular NucleusIngestive BehaviorL-GlutamateLEP-RLEPR ProteinLaboratoriesLateralLearningMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureModel SystemMotivationMurineMusNatureNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNociceptionOB ReceptorOB-RObesityOpiate AddictionOpiate DependenceOpiatesOpioidOvereatingParvalbuminsPatternPeptidesPopulationPropertyRegulationRewardsSatiationStimulusStructure of nucleus infundibularis hypothalamiSubcellular ProcessSynapsesSynapticWeight GainWeight IncreaseWeight LossWeight ReductionWorkabuse of drugsabused drugabused drugsabuses drugsaddictionaddictive disorderadiposityattenuateattenuatesawakebody weight gainbody weight increasebody weight lossbulimiccell typecorpulencediabetesdrug abuseddrug of abusedrugs abuseddrugs of abuseelectrophysiologicalendomicroscopyexperimentexperimental researchexperimental studyexperimentsfeedingfeeding-related behaviorsfeelingsglutamatergichypothalamicinterestleptin receptorleptin-binding proteinmicroendoscopyneuronalneuronal circuitneuronal circuitrynociceptivenutrient intake activityopioid addictionopioid dependenceopioid dependentoptogeneticspain behaviorpolyphagiasatietysynapsetherapeutic targetwt gainwt-loss
Description preview
Our interest is to understand how genetically identified cell types and their projections drive behaviors essential for survival. Using the mouse as our model system, we apply optogenetics and chemogenetics to manipulate neuronal circuits in awake, behaving mice. In addition, we use a combination of electrophysiology, fluorescence endomicroscopy,…
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