grant
Hyperglycemia and Adverse Pregnancy Outcome Study-Cardiovascular Health of HAPO Offspring (HAPO CVH)
Organization LURIE CHILDREN'S HOSPITAL OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20250-11 years oldActive Follow-upAdult ChildrenAdult DaughtersAdult OffspringAdult SonsAgeAmerican Heart AssociationArterial InjuryAtherogenicityBMIBMI percentileBMI z-scoreBehaviorBirthBloodBlood CellsBlood PressureBlood Reticuloendothelial SystemBody mass indexCardiovascular DiseasesCarotid ArteriesCarotid Artery InjuriesCarotid Artery TraumaChildChild YouthChildhoodChildren (0-21)ClinicalCohort StudiesConcurrent StudiesCord BloodCountryDNADNA MethylationDataDeoxyribonucleic AcidDevelopmentEarly identificationEchographyEchotomographyEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFastingFollow-Up StudiesFollowup StudiesFutureGestationGestational DiabetesGestational Diabetes MellitusHealthHealth StatusHyperglycemiaHypertensionIntergenerational transferInternationalInterventionIntervention StudiesInvestigationLevel of HealthLifeLife CycleLife Cycle StagesLife StyleLifestyleLipidsMeasuresMediatingMedical RecordsMedical UltrasoundMetabolicMothersNHLBINational Heart, Lung, and Blood InstituteOGTTObesityOral Glucose Tolerance TestOutcomeOutcome StudyParturitionPathway interactionsPeripheral Blood CellPhenotypePostpartum PeriodPregnancyPregnancy-Induced DiabetesPregnant WomenPreventionQuetelet indexResolutionRiskRoleSiteStandardizationTextureTimeTraumatic Carotid ArteriopathiesUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUmbilical Cord BloodVascular Hypertensive DiseaseVascular Hypertensive DisorderVisitWomanWorkaccelerated epigenetic ageaccelerated epigenetic agingaccelerated pace of epigenetic agingacceleration in epigenetic ageactive followupadiposityadult youthadverse pregnancy outcomeage related pathwaysagesaging associated mechanismaging mechanismaging pathwayaging related mechanismaging related pathwaysassess effectivenessbiological mechanism of agebiological pathways of agecardiometaboliccardiometabolic riskcardiometabolismcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular healthcarotid intima-media thicknesschild adipositychild obesitychildhood adipositychildhood obesitycorpulencecritical perioddetermine effectivenessdevelopmentaldiagnostic ultrasoundeffectiveness assessmenteffectiveness evaluationepigeneticallyepigenomeevaluate effectivenessexamine effectivenessexpectant motherexpectant womenexpecting motherexpecting womenfastedfaster epigenetic agingfaster rates of epigenetic agingfastsfetal cord bloodfollow upfollow-upfollowed upfollowuphealth assessmenthealth levelhigh blood pressurehigh riskhyperglycemichyperpiesiahyperpiesishypertensive diseasehypertensive disorderin uteroincreased epigenetic ageincreased epigenetic agingincreased rates of epigenetic agingindividuals who are pregnantinsightintergenerationalintervention researchinterventional researchinterventional studyinterventions researchintima medial thickeningintima-media thicknessintimal medial thickeningintrauterine environmentintrauterine milieukidslife coursematernal adipositymaternal obesitymaternal outcomemechanism regulating agingmechanisms involved in agingmortalitymother outcomeneonatal adiposityneonatal outcomenewborn adipositynewborn obesitynovelobese childrenobesity during childhoodobesity in childrenoffspringpathwaypathway involved in agingpediatricpediatric obesitypeople who are pregnantpost-partumpregnancy diabetespregnant femalespregnant motherspregnant peoplepregnant populationsprematureprematurityprimary outcomeprospectiverapid epigenetic agingrecruitresolutionssocial rolesonogramsonographysound measurementthose who are pregnantultrasoundultrasound imagingultrasound scanningwomen who are pregnantyoung adultyoung adult ageyoung adulthoodyoungster
Description preview
Project Summary
Halting the intergenerational transfer of cardiovascular disease (CVD) risk is a priority for NHLBI and the
American Heart Association (AHA). Yet, limited understanding around the timing, pathways, and mechanisms
underlying the observed associations between maternal gestational health and offspring cardiovascular health
(CVH)…
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