grant
Hydrogel matrices to study the role of inflammation and biological sex on aortic valve fibrocalcification
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 5 Jul 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202621+ years old2aR phosphoprotein I2ar peptide3-D3-Dimensional3D3D cell culture3D cultureATAC sequencingATAC-seqATACseqAdultAdult HumanAffectAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAortaAortic StenosisAortic Valve StenosisAortic valvular disordersAssay for Transposase-Accessible Chromatin using sequencingBasal Transcription FactorBasal transcription factor genesBlood flowBody TissuesBone MineralizationCBP geneCBP proteinCREB-binding proteinCREBBPCREBBP geneCalcifiedCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCardiac ValvesCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCellular Immune FunctionChromatinChromatin Remodeling ComplexChromatin Remodeling FactorCo-cultureCocultivationCocultureCoculture TechniquesCollagenCuesDNADataDeoxyribonucleic AcidDepositDepositionDifferences between sexesDiffers between sexesDiseaseDisease ProgressionDisorderDrugsDysfunctionEFRACEjection FractionEncapsulatedEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEta-1 proteinEta-1-Op proteinExposure toFamily suidaeFemaleFibroblastsFibrosisFunctional disorderGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGoalsHeart Valve DiseasesHeart ValvesHistonesHumanHydrogelsImageImmuneImmune responseImmunesIn SituIn VitroInflammationInflammatoryIntracellular Communication and SignalingLeft VentriclesLeft ventricular structureMacrophageMediatingMediatorMedicationMethodologyMethylationMiceMice MammalsMicroscopyModelingModern ManMolecularMolecular TargetMurineMusMyofibroblastMφOB-cadherinOsteoblastsPatientsPharmaceutical PreparationsPhenotypePhysiologic calcificationPhysiopathologyPigsPlayPopulationProcessProgressive DiseaseRNA SeqRNA sequencingRNAseqReceptor ProteinRegulationRoleSERPINE1SERPINE1 geneSeverity of illnessSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSuidaeSwineTestingTissuesTranscription Factor Proto-OncogeneTranscription factor genesVDCCValidationValvular Heart DiseasesValvular Heart DisorderVoltage-Dependent Calcium ChannelsWomanadulthoodagedantagonismantagonistaortic valveaortic valve defectaortic valve diseaseaortic valve disorderaortic valvular diseaseassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological sexbiological signal transductionbone sialoprotein 1bone sialoprotein Icadherin-11calcificationcardiac valve diseasecardiac valve disordercardiac valvular diseasechromatin modificationchromatin modifiercytokinedegenerative valvular heart diseasedisease severitydrug/agentearly T-lympocyte activation-1 proteinefficacy testingepigeneticallyfemale patientsheart valve disorderhigh riskhost responsehypertensiveimagingimmune functionimmune system responseimmunoresponsein vitro Modelin vivoinhibitorinsightinterstitial cellmalemenmimeticsmodel of animalmouse modelmurine modelosteoblast cadherinosteopontinpathophysiologypatients being femalepatients being womenpatients who are femaleporcinepromoterpromotorreceptorrecruitsecreted phosphoprotein 1sexsex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsialoprotein 1small molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolesuidsuper high resolutionsuperresolutiontargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic evaluationtherapeutic testingthree dimensionalthree dimensional cell culturetranscription factortranscriptome sequencingtranscriptomic sequencingultra high resolutionultra resolutionultrafine resolutionvalidationswomen patients♀♂
Description preview
ABSTRACT
Thirteen percent of adults over 75 suffer from aortic valve stenosis (AVS), a progressive disease that leads to
aberrant collagen deposition, leaflet stiffening, and eventual valve calcification at late stages. AVS is also
sexually dimorphic with men having a two-fold higher risk for developing direct calcification, whereas women
with…
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