grant
Hydrogel Delivery of Bacteriophage to Treat Wound Infections
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Aug 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffinityAnimalsAtomic MedicineBacteriaBacteria resistanceBacteria resistantBacterial InfectionsBacterial resistantBacteriophagesBiodistributionBody TissuesCapsidCaringCell BodyCellsChronicCirculationClinicalDiffuseDiffusionDiscipline of Nuclear MedicineDoseDrug KineticsEngineeringExhibitsExposure toFrequenciesGamma Camera ImagingGelGoalsHIVHealthHumanHuman Immunodeficiency VirusesHyaluronic AcidHydrogelsImageImaging ProceduresImaging TechnicsImaging TechniquesImaging technologyImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualInfectionInfectious Skin DiseasesInfective cystitisIntravenousKineticsLAV-HTLV-IIILabelLymphadenopathy-Associated VirusMediatingMiceMice MammalsMicrobial BiofilmsModelingModern ManModificationMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMurineMusNuclear MedicineP aeruginosaP. aeruginosaPeptidesPeriprosthetic joint infectionPhagesPharmacodynamicsPharmacokineticsPolymersPre-Clinical ModelPreclinical ModelsPseudomonas aeruginosaPseudomonas pyocyaneaRadioactive IsotopesRadioisotope ScanningRadioisotopesRadiolabeledRadiology / Radiation Biology / Nuclear MedicineRadionuclide ImagingRadionuclidesResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugS aureusS. aureusSPECTSPECT imagingSafetyScintigraphySightSingle-Photon Emission-Computed Radionuclide TomographySiteSkinStaph aureusStaphylococcus aureusStructureTc 99mTechnetium 99mTechnologyTestingTimeTissuesTopical Drug AdministrationTopical applicationToxic effectToxicitiesTreatment ProtocolsTreatment RegimenTreatment ScheduleViralVirusVirus-HIVVisionWorkWound InfectionWound Repairanti-microbialanti-microbial resistant pathogenantimicrobialantimicrobial resistant pathogenapply topicallybacteria infectionbacterial diseasebacterial resistancebacterial virusbiofilmbladder infectionchronic skin woundchronic woundcrosslinkcutaneous infectiondeliver topicallydensitydesigndesigningdiffuseddiffusesdiffusingdiffusionsear infectionimagingimaging platformin vivoinfected skininfected woundinnovateinnovationinnovativemicrobe pathogenmicrobial pathogenmouse modelmulti-drug resistantmultidrug resistantmurine modelnovelpathogenpathogenic microbephysical propertypolymerpolymericpreventpreventingprosthetic joint infectionradiolabelingradiologically labeledradionuclide imaging/scanningradionuclide scanningresistance to Bacteriaresistance to Bacterialresistantresistant to Bacteriaresistant to Bacterialsingle photon emission computed tomographyskin infectiontechnology platformtechnology systemtissue woundtopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttreat topicallytreat woundvisual functionweaponswoundwound care dressingwound dressingwound environmentwound healingwound managementwound recoverywound resolutionwound therapeuticswound therapywound treatmentwoundingwounds
Description preview
Abstract Summary
Bacteriophages—viruses that kill bacteria—are a powerful weapon against anti-microbial resistant (AMR)
pathogens, including skin, bladder, and ear infections caused by the bacterium Pseudomonas aeruginosa (Pa).
Phages require sustained exposure to kill bacteria effectively but unfortunately are rapidly cleared from
circulation,…
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