grant
Human Studies of Diet and Nutrition
Organization DIVISION OF CANCER EPIDEMIOLOGY AND GENETICSLocation UNITED STATES
NIHUS FederalResearch GrantFY20254-Androstene-3,17-dioneAgeAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAndrost-4-ene-3,17-dioneAndrostenedioneAntioxidantsAquadiolAscorbic AcidAutoantibodiesBindingBioavailabilityBiological AvailabilityBlood PlasmaBlood SerumBreast CancerBreast Cancer Risk FactorCaloric IntakeCaloriesCancersCardiovascular DiseasesCarotenes and CarotenoidsCarotenoidsChemopreventiveChemopreventive AgentClinical NutritionClinical TrialsColorectal CancerDHA SulfateDHEA SulfateDNA DamageDNA InjuryDehydroepiandrosterone SulfateDehydroisoandrosterone SulfateDietDiet RecordsDiet and NutritionDietary AlcoholDietary FatsDietary RecordsDimenformonDiogynDiogynetsDoseDrug KineticsEndocrine Gland SecretionEnergy ExpenditureEnergy IntakeEnergy MetabolismEsophageal CancerEsophagus CancerEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogensEstrone-SulfateEtOH drinkingEtOH useEvaluationFood DiariesFood frequency questionnaireGestationHormonesHumanIGF-1IGF-IIGF-I-SmCInsulin-Like Growth Factor 1Insulin-Like Growth Factor IInsulin-Like Somatomedin Peptide IIntakeIntervention StrategiesLeptinLipidsLipoproteinsMalignant Breast NeoplasmMalignant Esophageal NeoplasmMalignant Esophageal TumorMalignant NeoplasmsMalignant TumorMalignant Tumor of the EsophagusMalignant neoplasm of esophagusMensesMenstrual cycleMenstruationMetabolicMethodological StudiesMicronutrientsModern ManMolecular InteractionNulliparasNulliparityNulliparousNutrition ResearchNutritional StudyOb Gene ProductOb ProteinObese Gene ProductObese ProteinObservation researchObservation studyObservational StudyObservational researchOvocyclinOvocylinOxidative StressPharmacokineticsPhysical activityPhysiologic AvailabilityPlasmaPlasma SerumPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePrasterone SulfatePre-MenopausePre-menopausal PeriodPregnancyPremenopausalPremenopausal PeriodPremenopauseProbabilistic ModelsProbability ModelsProgynonQuestionnairesResearchReticuloendothelial System, Serum, PlasmaRoleSHBGSHBG geneSafetySe elementSeleniumSerumSex Hormone-Binding Globulin GeneSolateneSomatomedin CStatistical ModelsTestosteroneTherapeutic AndrostenedioneTherapeutic EstradiolTherapeutic EstrogenTherapeutic HormoneTherapeutic TestosteroneTrans-TestosteroneUS Department of AgricultureUSDAUnited States Department of AgricultureVIT CVitamin CWomanafter menopauseage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage induced alterationsage induced changesage related alterationsage related changesage specific alterationsage specific changesagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakealpha-carotenealterations with ageanti-carcinogenicautoimmune antibodyautoreactive antibodybeta,beta-Carotenebeta-carotene-3,3'-diolbreast cancer riskcaloric dietary contentcancer chemopreventioncardiovascular disordercardiovascular riskcardiovascular risk factorcarotenoid biosynthesischanges with agechemoprevention agentdelta-4-Androstenedionedietarydietary lipiddietsdoubly-labeled waterestrone-3-sulfateethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol usefeedingfollowing menopausehigh-fat/low-fiber dietimprovedinsulin sensitivitymalignancymalignant breast tumormenmenstrual periodmonthly periodmonthly periodsneoplasm/canceroesophageal cancerparouspast menopausepost-menopausalpostmenopausalpostmenopausal statuspre-menopausalpremenopausal statussafety assessmentself reactive antibodysocial rolestatistical linear mixed modelsstatistical linear modelsurinaryzeaxanthinα-caroteneβ-Carotene
Description preview
OBJECTIVE: The objectives of this research are to evaluate the metabolic effects of dietary changes relevant to cancer and to assess the safety, pharmacokinetics, bioavailability, and mechanisms of action of macro- and micronutrients with cancer chemoprevention potential. BACKGROUND: Clinical nutrition studies provide information that helps bridge…
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