grant
Human Intracerebral Hemorrhage: Impact of Hematoma Size, Hemolysis and Iron Overload on Edema and White Matter Survival by MRI
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 15 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AcuteAddressAffectAnimal ModelAnimal Models and Related StudiesAnimalsAnisotropyBiological MarkersBleedingBlood erythrocyteBody TissuesBrainBrain Nervous SystemCerebral Brain HemorrhageCerebral EdemaCerebral HemorrhageCerebral Parenchymal HemorrhageCerebral hemisphere hemorrhageCerebromalaciaCerebrumCerebrum HemorrhageChronic PhaseClinicalClinical TrialsClottingCoagulationCoagulation ProcessContralateralCytolysisDWI (diffusion weighted imaging)DWI-MRIDataDeferoxamineDeferoxamine BDeferoximineDeferrioxamine BDesferioximineDesferrioxamineDesferrioxamine BDesferroxamineDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDropsyDrug TherapyEdemaEncephalomalaciaEncephalonErythrocytesErythrocyticEvaluationFamily suidaeFe chelationFe elementFe metabolismFe overloadFiberFutureGrantHealthHematomaHemolysisHemorrhageHistologyHumanHydropsInflammationInflammatory ResponseInjuryIntracerebral HemorrhageIntravenousIronIron ChelatesIron Chelating AgentsIron ChelationIron OverloadIron chelatorLobarLysisMR ImagingMR TomographyMRIMRI biomarkerMRI markerMRIsMagnetic Resonance ImagingMapsMarrow erythrocyteMechanicsMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModelingModern ManNMR ImagingNMR TomographyNatural HistoryNerve CellsNerve UnitNervous System PhysiologyNeural CellNeurocyteNeurologic functionNeurological functionNeuronsNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresOutcomePatient RecruitmentsPatientsPharmacological TreatmentPharmacotherapyPhasePigsPrognosisRecoveryRed Blood CellsRed CellReportingSeverity of illnessSocietiesSuidaeSurgicalSurgical InterventionsSurgical ProcedureSurrogate MarkersSwineTechniquesTestingTherapeuticTimeTissuesVariantVariationWorkZeugmatographybio-markersbiologic markerbiomarkerblood corpusclesblood lossbrain Febrain atrophybrain ironbrain tissuecerebralcerebral Fecerebral atrophycerebral ironcortical atrophydMRIdiffusion tensor imagingdisease severitydrug interventiondrug treatmenterythrolysisfunctional improvementimage guidanceimage guidedimprove functionimprovedimproved functional outcomesinjuriesinnovateinnovationinnovativeiron in the brainiron metabolismmagnetic resonance imaging biomarkermagnetic resonance imaging markermechanicmechanicalmodel of animalmortalitynerve cell deathnerve cell lossnervous system functionneuron cell deathneuron cell lossneuron deathneuron lossneuron toxicityneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal toxicityneurotoxicneurotoxicitynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachparticipant recruitmentpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsporcinepre-clinicalpreclinicalprognosticationsubstantia albasuidsurgerysurrogate bio-markerssurrogate biomarkerswhite matterwhite matter injury
Description preview
Project Abstract – There is currently no evidence for an established treatment paradigm for
intracerebral hemorrhage (ICH). The most recent clinical trials on hematoma evacuation and
iron chelator treatment have not shown a significant improvement in neurological function. No
objective surrogate markers of disease severity currently exist to guide…
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