grant

Human Epidemiologic and Toxicity Assessment of Microcystin Mixture Effects on Hepatic Disease and Cancer

Organization NORTH CAROLINA STATE UNIVERSITY RALEIGHLocation RALEIGH, UNITED STATESPosted 21 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20263-D modeling3D modelingAlgaeBiological MarkersBiological MonitoringBiomedical ResearchChemicalsChronicCommunitiesDataData BanksDatabanksDoseEnvironmentEnvironmental PollutantsEpidemiologyExposure toFatty LiverFemaleGeographyGoalsGuidelinesHealthHep G2HepG2HepG2 cell lineHepatic CancerHepatic DisorderHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatomaHepatotoxic effectHepatotoxicityHumanIndividualLiverLiver Cells CarcinomaLiver FibrosisLiver SteatosisLiver ToxicityLiver diseasesMCYST-LRMalignant neoplasm of liverMeasuresMediatingMetabolicMiceMice MammalsModelingModern ManMurineMusNAFLDNIEHSNational Institute of Environmental Health SciencesNested Case-Control StudyNorth CarolinaOceansPFASParticipantPersonsPoly-fluoroalkyl substancesPopulationPrimary carcinoma of the liver cellsPublic HealthQuestionnairesR-Series Research ProjectsR01 MechanismR01 ProgramResearch GrantsResearch Project GrantsResearch ProjectsResearch SpecimenRiskRisk AssessmentSea-FoodSeafoodSpecimenSystemTestingToxic effectToxic effect on liver cellsToxicitiesToxicity TestingToxicity TestsToxinbio-markersbiologic markerbiomarkerbiomonitoringbrown tidecarcinogenicityco-exposuresco-occurring exposurecohortcombined exposurecomplex exposureconcurrent exposurecyanobacterium toxin Icyanoginosin LRdata depositorydata repositorydata set repositorydataset repositorydrinking waterenvironmental contaminantepidemiologicepidemiologicalexperienceexperimentexperimental researchexperimental studyexperimentsexposure mixturefibrotic liverharmful algal bloomshepatic body systemhepatic diseasehepatic fibrosishepatic organ systemhepatic steatosishepatic toxicityhepatopathyhepatosteatosishepatoxicityhuman dataliver cancerliver carcinomaliver disorderliver malignancymalemalignant liver tumormicrocystinmicrocystin-LRmixed exposuremouse modelmurine modelnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseaseperfluorinated alkyl substancesperfluoro octane sulfonateperfluoro-octane sulfonic acidperfluoroalkyl substancesperfluoroalkylated substancesperfluorooctane sulfonateperfluorooctane sulfonic acidperfluorooctanesulfonateperfluorooctanesulfonic acidpollutantpolyfluorinated alkyl substancespolyfluoroalkyl substancessecondary analysissimultaneous exposuressoundspheroidsthree-dimensional modelingtoxic metaluptake
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ABSTRACT – RESEARCH PROJECT 2
The primary objective for Project 2 of the North Carolina Center for Coastal Algae, People, and Environment (NC C-CAPE), is to define the toxicity of human and environmentally relevant microcystin (MC) mixtures found in recent harmful algal blooms (HABs) and seafood biomonitoring efforts in Project 1, and HAB…

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Human Epidemiologic and Toxicity Assessment of Microcystin Mixture Effects on Hepatic Disease and Cancer — NORTH CAROLIN | Dev Procure