grant
Human Airway Macrophage Immunity in Tuberculosis: Defining Early Determinants of Infection
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026(TNF)-αACT2AT744.1ATAC sequencingATAC-seqATACseqAct-2AcuteAddressAffectAntibodiesAntitubercular AgentsApoptoticAssayAssay for Transposase-Accessible Chromatin using sequencingB-Cell Differentiation Factor GeneB-Cell Stimulatory Factor 2 GeneBSF-2 GeneBSF2 GeneBeta-2 Gene InterferonBioassayBiological AssayBiological MarkersBloodBlood Reticuloendothelial SystemBlood monocyteBronchioalveolar LavageBronchoalveolar LavageBronchoalveolar Lavage FluidBronchopulmonary LavageCCL4CCL4 geneCachectinCell BodyCellsChemokine (C-C Motif) Ligand 4Chemokine, CC Motif, Ligand 4Chemotactic CytokinesClinicClinicalCohort StudiesCollaborationsCollectionCountyDataDisease ProgressionEffector CellEnrollmentEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGoalsGrowthHSF GeneHealth ResourcesHepatocyte Stimulatory Factor GeneHeterogeneityHomologous Chemotactic CytokinesHost DefenseHumanHybridoma Growth Factor GeneIFNIFN-GammaIFN-gIFN-γIFNB2 GeneIFNGIFNγIL-6 GeneIL6IL6 geneImmuneImmune Activation 2Immune InterferonImmune responseImmunesImmunityIn VitroIndividualInfectionInfection ControlInfection preventionInflammatoryInhalationInhalingIntercrinesInterferon GammaInterferon Type IInterferon Type IIInterferonsInterleukin 6 (Interferon, Beta 2) GeneInterleukin-6 GeneKnock-outKnockoutKnowledgeLabelLinkLung LavageLung TBLung TuberculosisM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMIP1BMIP1B1MTB infectionMacrophageMacrophage Inflammatory Protein 1-BetaMacrophage-Derived TNFMarrow monocyteMeasuresMediatingMetabolicMiceMice MammalsMinnesotaModern ManMolecularMonocyte-Derived TNFMultiomic DataMurineMusMycobacterial InfectionMycobacterium InfectionsMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNatureNon-Polyadenylated RNAOutcomePathway interactionsPatientsPatternPersonsPhenotypePlayPopulationPositionPositioning AttributePrevent infectionPreventative therapyPreventionPreventive therapyProductionPropertyPublic HealthPulmonary TBPulmonary TuberculosisRNARNA ExpressionRNA Gene ProductsReportingResearchRibonucleic AcidRoleSCYA4SIS cytokinesShapesSmall Inducible Cytokine A4T cell differentiationT-CellsT-LymphocyteTB immunityTB infectionTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTimeTissue GrowthTrainingTranscriptionTransmissionTuberculin TestTuberculosisTuberculostatic AgentsTumor Necrosis FactorTumor Necrosis Factor-alphaViral Gene ProductsViral Gene ProteinsViral ProteinsVirulentVulnerable PopulationsWorkanti-TBanti-microbialanti-tuberculosisantiTBantimicrobialassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbasebasesbio-markersbiologic markerbiomarkerbronchiolar alveolar lavagebronchopulmonary lavage therapycell typechemoattractant cytokinechemokinecig5 gene productcohortcohort research studycohort surveycomputer based predictioncytokinedifferential expressiondifferentially expresseddisseminated TBdisseminated tuberculosisenrollepigeneticallyexperimentexperimental researchexperimental studyexperimentsflow cytophotometryfunctional outcomeshealthy volunteerhost responseimmune system responseimmunity against M. tuberculosisimmunity against Mtbimmunity against Mycobacterium tuberculosisimmunity against TBimmunity against tuberculosisimmunity in tuberculosisimmunity to TBimmunity to tuberculosisimmunoresponseimprovedindexinginfection due to Mycobacterium tuberculosisinsightinterstitiallFN-Gammamonocytemtbmultiomicsmultiple omic datamultiple omicsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypanomicspathwaypredictive modelingprogramspulmonaryrecruitresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic targetthymus derived lymphocytetranscriptional differencestranscriptomicstransmission processtuberculin skin testtuberculosis immunitytuberculosis infectiontuberculous spondyloarthropathyviperinvirus proteinvulnerable groupvulnerable individualvulnerable people
Description preview
ABSTRACT
Clinical tuberculosis outcomes are shaped by host immune responses to Mycobacterium tuberculosis (Mtb),
yet the specific innate immune phenotypes that drive Mtb control remain unclear. Human airway macrophages,
the first pulmonary cells to encounter inhaled Mtb, differ in their innate ability to prevent infection. Large cohort
studies…
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