grant
How retinal silencing restores synaptic strength in visual cortex of adult amblyopia
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old1 year of age1 year old21+ years oldAMPA ReceptorsAccountingAdultAdult HumanAmblyopiaAnatomic SitesAnatomic structuresAnatomyAnimalsAssayBehavioralBinocular VisionBioassayBiological AssayBrainBrain Nervous SystemCase StudyCatsCats MammalsCharacteristicsChemosensitizationChemosensitization/PotentiationChildChild YouthChildren (0-21)ClinicalDepth PerceptionDisparitiesDisparityDomestic CatsDorsalDysfunctionEffectivenessElectrophysiologyElectrophysiology (science)EncephalonEyeEye DominanceEyeballFeline SpeciesFelis catusFelis domesticaFelis domesticusFelis sylvestris catusFrequenciesFunctional disorderHumanImpairmentIn VitroInjuryKnowledgeLateral Geniculate BodyLifeLocal anesthesiaLong-Term DepressionLong-Term Synaptic DepressionMeasuresMediatingMiceMice MammalsModern ManModificationMonkeysMotionMurineMusNerve CellsNerve UnitNeural CellNeural TransmissionNeurocyteNeuronsNeurophysiology / ElectrophysiologyObstructionOcular DominancePatternPhasePhysiopathologyPlayPopulationPotentiationPrimary visual cortexRecoveryResearchRetinaSightStereopsisStereoscopic VisionStimulusStriate CortexStriate areaSynapsesSynapticSynaptic TransmissionSynaptic plasticityTestingThalamic structureThalamusTranslatingVisionVision DisordersVisual AcuityVisual CortexVisual DisorderVisual PathwaysVisual disabilityVisually disabledWorkadulthoodage 1 yearaged 1 yearaged one yeararea striatacase reportcatsconventional therapyconventional treatmentcritical perioddeprivationearly childhoodelectrophysiologicalexperienceimprovedinfancyinfantileinjuriesinnovateinnovationinnovativeinsightkidslateral geniculatelateral geniculate nucleusmonocular deprivationmouse modelmurine modelneuronalnew approachesnew growthnovel approachesnovel strategiesnovel strategyold ageone year of ageone year oldpathophysiologypost-synaptic nervespost-synaptic neuronspostnatalpostsynaptic nervespostsynaptic neuronspreventpreventingresponserestore sightrestore visionsight restorationspatial visionstandard carestandard of carestandard treatmentsynapsesystematic reviewthalamicvision disabilityvision restorationvisual corticalvisual depth perceptionvisual functionyoungster
Description preview
Amblyopia is a prevalent form of visual disability that arises during infancy and early
childhood when inputs to the visual cortex from the two eyes are poorly balanced (for
example, by misalignment of the eyes, asymmetric refraction, or blocked vision of one
eye). Characteristics of amblyopia are poor visual acuity in one eye, and an attendant…
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