grant
How NTS NPY neurons alter NTS circuitry to promote food intake
Organization WASHINGTON STATE UNIVERSITYLocation PULLMAN, UNITED STATESPosted 1 Apr 2024Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20264-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAgonistAminalonAminaloneApoplexyAppetite StimulantsAppetite-Stimulating DrugsArcuate NucleusAreaBehaviorBrain StemBrain Vascular AccidentBrain regionBrainstemCaloriesCardiovascular DiseasesCatecholaminesCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeConsumptionDataDiabetes MellitusDietDiet rich in fats and sugarsEatingElectrophysiologyElectrophysiology (science)EquilibriumFastingFatsFatty acid glycerol estersFiberFoodFood IntakeGABAGoalsHealthHigh Fat DietImageInfundibular NucleusInjectionsKnowledgeLengthLevarterenolLevonorepinephrineMediatingMetabolicModalityMolecularNPY Y2 receptorNPY2 receptorNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNoradrenalineNorepinephrineNucleus Tractus SolitariiNucleus solitariusObesityPathway interactionsPeptidesPharmacologyPhysiologicPhysiologicalPopulationPreventative strategyPrevention strategyPreventive strategyProcessPublic HealthReceptor ProteinResearchSatiationSolitary NucleusStrokeStructure of nucleus infundibularis hypothalamiSympathinsTestingTherapeuticUnited StatesWeight GainWeight Increaseadipositybalancebalance functionbody weight gainbody weight increasebrain attackcaloriecardiovascular disordercerebral vascular accidentcerebrovascular accidentcorpulencediabetesdiet high in fat and sugardietselectrophysiologicalexpectationfastedfastsgamma-Aminobutyric Acidhigh-fat/sugar dietimagingimprovedinnovateinnovationinnovativeinterdisciplinary approachmultidisciplinary approachneuronalneuropeptide Y Y(2) receptorneuropeptide Y2 receptorneurotransmitter releasenovelobesity developmentobesity interventionobesity therapyobesity treatmentoptogeneticsorexigenicpathwaypreventpreventingreceptorsatietysexsolitary tract nucleusstrokedstrokessugarwt gainγ-Aminobutyric Acid
Description preview
Obesity is a major health problem in the United States and a leading contributor to cardiovascular disease,
diabetes mellitus and stroke. One region essential for the control of meal size is the nucleus of the solitary
tract (NTS) in the brainstem. Vagal afferent fibers carrying different types of satiety information from the GI
terminate in the…
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