grant
How Hedgehog Contributes to Centrally Mediated Energy Homeostasis?
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 20 Mar 2018Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202621+ years old3'5'-cyclic ester of AMPAcuteAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)AdultAdult HumanAffectAllelesAllelomorphsAttenuatedAutoregulationBinding ProteinsBody CompositionBody TissuesBrainBrain Nervous SystemCardiac DiseasesCardiac DisordersCell BodyCell Communication ProcessCell Communication and SignalingCell SignalingCell Signaling ProcessCellsCiliaClinicalCollaborationsCommunicationCyclic AMPCyclic AMP-Dependent Protein KinasesDevelopmentDiabetes MellitusElectrophysiologyElectrophysiology (science)Embryo DevelopmentEmbryogenesisEmbryonic DevelopmentEncephalonEndocrineEndocrine Gland SecretionErinaceidaeFastingFeeding behaviorsG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingG-Protein-Coupled ReceptorsGPCRGPCR SignalingGeneticHealthHealth Care CostsHealth CostsHeart DiseasesHedgehog (Hh) signal transduction pathwayHedgehogsHomeostasisHormonesHumanHyperphagiaHypothalamic structureHypothalamusImmunofluorescenceImmunofluorescence ImmunologicIn Situ HybridizationIn VitroIngestive BehaviorIntracellular Communication and SignalingLearningLeptinLigand Binding ProteinLigand Binding Protein GeneLigandsMCH1RMCHR1MCHR1 geneMapsMeasuresMediatingMediatorMiceMice MammalsMicro-tubuleMicrotubulesModern ManMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyOb Gene ProductOb ProteinObese Gene ProductObese ProteinObesityOrganOrganismOutputOvereatingOverweightPKAPathway interactionsPatternPeripheralPhysiological HomeostasisPlayProcessProtein BindingProtein Kinase AReporterResearchRoleSLC1Signal TransductionSignal Transduction SystemsSignalingSourceSubcellular Signaling ProcessTestingTissuesUnited Statesadenosine 3'5' monophosphateadiposityadulthoodappendageattenuateattenuatesaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbound proteincAMPcAMP-Dependent Protein Kinasescell typeciliopathycorpulencedevelopmentaldiabetesdiet-associated obesitydiet-induced obesitydiet-related obesitydifferentiation factorselectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfastedfastsfeedingfeeding-related behaviorsglia signalingglial signalingheart disorderhedgehog signal transductionhedgehog signalinghedgehog signaling pathwayhh signal transductionhh signaling pathwayhypothalamicin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivoinsightliving systemmelanin-concentrating hormone receptor 1morphogenic factorsmorphogensmortalitynerve signalingneural signalingneuronalneuronal signalingneurotransmissionnovelnutrient intake activitypathwaypharmacologicpolyphagiapreventpreventingrestraintsmoothened signaling pathwaysocial roletool
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PROJECT SUMMARY
Obesity contributes to heart disease and diabetes, leading to early mortality. Two-thirds of adults in the United
States are overweight, adding to healthcare costs. Yet, energy homeostasis is not fully understood. Recent
research has revealed that primary cilia on neurons in the brain play a crucial role in preventing overeating…
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