grant
How cell maturation is regulated by circadian and metabolic rhythms
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 12 Jun 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026AreaB9 endocrine pancreasBacteriaBasal Transcription FactorBasal transcription factor genesBiologic ModelsBiological ModelsBiological RhythmBody TissuesCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell DifferentiationCell Differentiation processCell FunctionCell MaturationCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyChronicChronobiologyCyclicityDevelopmental BiologyDiagnosisDiseaseDisorderDysfunctionEarthEndocrine PancreasFunctional disorderGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGoalsHealthHeart VascularHepatic CellsHepatic Parenchymal CellHepatocyteHourHumanIn SituIn VitroInvestigationIslands of LangerhansIslets of LangerhansKnowledgeLifeLife StyleLifestyleLinkLiverLiver CellsMaintenanceMammalian CellMapsMetabolicMiceMice MammalsModel SystemModern ManMolecularMurineMusNesidioblastsPancreatic IsletsPars endocrina pancreatisPeriodicityPhenotypePhysiologyPhysiopathologyPlanet EarthPlayProtein BiosynthesisRegenerative MedicineResearchRhythmicityRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleRotationShapesSubcellular ProcessSyndromeSystemTissuesTranscription Factor Proto-OncogeneTranscription factor genescell biologycellular differentiationcircadiancircadian clockcircadian pacemakercirculatory systemdisease diagnosisfeedinghepatic body systemhepatic organ systemin vivoin vivo Modelinsightmulti-modalitymultimodalityneuralnovelpathophysiologyprogramsprotein synthesisregenerative tissuesocial roletranscription factor
Description preview
Project Summary/Abstract
The overall goal of my research program is to mechanistically understand how circadian and metabolic rhythms
shape how fully differentiated cells become functionally specialized, or “mature”. Cycles in energy availability,
due to earth’s 24-hour rotation, are the oldest, most consistent environmental input for life on…
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