grant
Host factors in shigellosis
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 Dec 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY20260-11 years old21+ years old5 year old5 years of ageActinsAcuteAdultAdult HumanAffectAnimal ModelAnimal Models and Related StudiesAntibiotic TherapyAntibiotic TreatmentAntimicrobial ResistanceBacillary DysenteryBackBacteriaBloodBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemBlood VesselsBloody diarrheaBody TissuesCell BodyCell Death InhibitionCellsCellular MatrixCellular biologyCessation of lifeChildChild YouthChildren (0-21)ColonCytoskeletal SystemCytoskeletonCytosolDataDeathDendritic CellsDevelopmentDiseaseDisorderDomestic RabbitDorsumDoseDrugsDysenteryEducational MainstreamingEpithelial CellsEpitheliumExpression SignatureFecesFoundationsGene Expression ProfileHemorrhagic colitisHemorrhagic diarrheaHost FactorHost Factor ProteinHumanHuman VolunteersImmuneImmune infiltratesImmune responseImmunesIn VitroIndividualInfantInfectionInfection ControlInfectious Diarrheal DiseaseIntegration Host FactorsIntestinalIntestinal MucosaIntestinesInvadedKnowledgeLaboratoriesLamina PropriaLesionM cellMacrophageMainstreamingMarrow NeutrophilMediatingMedicationModelingModern ManMolecularMotilityMucosaMucosal TissueMucous MembraneMφNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteOralOryctolagus cuniculusPathogenesisPatientsPhagocytesPhagocytic CellPharmaceutical PreparationsPhasePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPreventative interventionProcessPublishingRNA SeqRNA sequencingRNAseqRabbitsRabbits MammalsResolutionRiskRoleRouteS flexneriS. flexneriSeminalShigella DysenteryShigella InfectionsShigella flexneriSideSmall IntestinesSupporting CellSymptomsSystemT3SSTherapeutic InterventionTissuesTransmissionType III Secretion SystemType III Secretion System PathwayUlcerUlcerationVeiled Cellsachievement Mainstream Educationacute infectionadulthoodage 5age 5 yearsamebocyteanti-microbial resistantbacteria pathogenbacterial disease treatmentbacterial infectious disease treatmentbacterial pathogenbowelcell biologycell typedesigndesigningdevelopmentaldiarrheal diseasediarrheal illnessdrug/agententeral pathogenenteric pathogenenteropathogenexperiencefive year oldfive years of agegene expression patterngene expression signaturehost responseimmune cell infiltrateimmune system responseimmunoresponseintervention for preventionintervention therapyintestinal pathogenintestine pathogenintracellular skeletonkidsmicrobialmodel of animalneutrophilnon-human primatenonhuman primatepathogenpathogenic bacteriaprevention interventionpreventional intervention strategypreventive interventionrational designregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresistance strainresistance to anti-microbialresistant strainresistant to antimicrobialresolutionsresponseshigellosissmall bowelsocial rolestooltissue culturetissue regenerationtissue regrowthtissue renewaltissue specific regenerationtranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtransmission processtype 3 secretion systemunpublished worksvascularyoungster
Description preview
Abstract
The intestinal pathogen Shigella flexneri is the causative agent of bacillary dysentery and is responsible for
more than 250 million cases of dysentery annually, resulting in more than 200,000 deaths. The disease results
from epithelial cell infection in the colon, leading to mucosal ulceration, vascular lesions and massive immune
cell…
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