grant
Host-Dependent Mechanisms that Guide the Longitudinal Dynamic of Sites of SIV Integration
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusATAC sequencingATAC-seqATACseqAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAnimalsAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingAutoregulationAwardBlood PlasmaCancersCardiovascular DiseasesCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular AssayCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessChromatinCollaborationsDNADataData AnalysesData AnalysisDeoxyribonucleic AcidDiabetes MellitusDisease ProgressionEarly identificationEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFrequenciesGene ExpressionGene TranscriptionGenesGenetic TranscriptionGenomeHIVHIV InfectionsHIV-1HIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHealth Care SystemsHeterogeneityHomeostasisHost FactorHost Factor ProteinHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1ImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune RegulatorsImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunomodulatorsInfectionInflammationIntegration Host FactorsKnowledgeLAV-HTLV-IIILocationLong-term infectionLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated VirusLymphatic nodesM mulattaM. mulattaMacaca mulattaMacaca rhesusMalignant NeoplasmsMalignant TumorMapsModern ManMolecularMultiomic DataOncogenesisOutcome StudyPBMCPeripheral Blood Mononuclear CellPersonsPhysiological HomeostasisPlasmaPlasma SerumPlayPredispositionPremature AgingPremature aging syndromeProteinsProvirus IntegrationProvirusesRNA ExpressionResearchResidualResidual stateReticuloendothelial System, Serum, PlasmaRhesus MacaqueRhesus MonkeyRiskRoleSIVSamplingShapesSimian Immunodeficiency VirusesSiteSubcellular ProcessSusceptibilityTestingTherapeuticTimeTranscriptionVirusVirus IntegrationVirus-HIVWhole Bloodantiretroviral therapyantiretroviral treatmentassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcardiovascular disordercell assaychallenge in rhesus macaqueschronic infectionco-morbidco-morbiditycommensal bacteriacommensal bacterial speciescomorbiditycomputer based predictioncytokinedata integrationdata interpretationdiabetesdrivingepigeneticallyepigenomeglobal gene expressionglobal healthglobal transcription profilehealth care burdenimmune functionimmune modulatorsimmune senescenceimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesimmunosenescenceinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinnovateinnovationinnovativeinsightintegration sitelymph glandlymph nodeslymphnodesmalignancymultiple omic dataneoplasm/cancernon-human primatenonhuman primatepersistent infectionpredictive modelingpredictive signaturepreferencepreventpreventingprogramsrhesus challengerhesus macaque challengerhesus monkey infectionscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuccesstherapeutic induction of senescencetherapeutic targettherapy caused senescencetherapy induced cell senescencetherapy induced cellular senescencetherapy induced senescencetranscriptometreatment induced senescencetumorigenesisviral genome integrationviral integrationviral reboundvirus genome integrationvirus rebound
Description preview
Project Summary
HIV integrates into the host genome and enters a state of latency, enabling infected cells to
escape immune recognition and clearance. Eliminating the latent reservoir will require an
understanding of the early host mechanisms that regulate latency establishment and
mechanisms that reinforce latency during ART suppression. This can…
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