grant
Hormonal and behavioral dysregulation following exposure to antiretrovirals and chronic cocaine
Organization DREXEL UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AIDS VirusAIDS preventionAbstinenceAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdherenceAffectAllopregnanoloneAnti-Retroviral AgentsAstrocytesAstrocytusAstrogliaAttenuatedBehaviorBehavioralBody TissuesBrainBrain Nervous SystemCapsidCell Communication and SignalingCell SignalingCellular Immune FunctionChronicCocaineCorpus Luteum HormoneCoupledCyclicityDREADDsDataDelta4-pregnene-3,20-dioneDevelopmentDiestrusDrug ExposureDrug ModulationDrug usageDrug userDrugsEncephalonEndocrine Gland SecretionEndocrine systemEndocrine/Metabolic Organ SystemEstrous CycleEstrusExhibitsExposure toFemaleFormulationGeneticHIVHIV InfectionsHIV PreventionHIV individualsHIV infected individualsHIV infected personsHIV interventionHIV peopleHIV positive individualsHIV positive peopleHIV riskHIV therapeuticHIV therapyHIV treatmentHIV viral infectionHIV virus infectionHIV-1 infectionHIV-1 interventionHIV-1 preventionHIV-1 therapeuticHIV-1 therapyHIV-1 treatmentHIV/AIDS preventionHealthHistoryHormonalHormonal SystemHormonesHuman Immunodeficiency Virus therapyHuman Immunodeficiency Virus treatmentHuman Immunodeficiency VirusesHypothalamic structureHypothalamusImmuneImmune systemImmunesImpairmentIndividualInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1Inflammatory ResponseInjectionsIntracellular Communication and SignalingLAV-HTLV-IIILymphadenopathy-Associated VirusMeasuresMedialMediatorMedicationMenstrual cycleMetabolic/Endocrine Body SystemMethodsMiceMice MammalsMicroinjectionsModelingMonitorMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuroimmuneNeuronsNucleus AccumbensOutcomeOvaryPLWHPWHPWUDPeriodicityPharmaceutical PreparationsPhasePopulationPrEPPre-Clinical ModelPreclinical ModelsPregn-4-ene-3,20-dionePregnenedionePreoptic AreasPrevent HIVPreventionProgesteroneRecording of previous eventsRegulationRelapseRewardsRhythmicityRiskRisk FactorsRoleSignal TransductionSignal Transduction SystemsSignalingSubstance Use DisorderTestingTherapeutic ProgesteroneTissuesTreatment outcomeViralVirus-HIVWorkanti-retroviralantiretroviral therapyantiretroviral treatmentastrocytic gliaattenuateattenuatesbiological signal transductioncell typecocaine behaviorcocaine exposurecocaine motivated behaviorscocaine relapsecocaine related behaviorscocaine seekingcocaine-associated behaviorscocaine-exposedconditioningcravingcytokinedesigner receptors exclusively activated by designer drugsdevelopmentaldrug adherencedrug compliancedrug cravingdrug relapsedrug seeking behaviordrug usedrug/agenteffective therapyeffective treatmentendocrine gland/systemestrousexperienceexperimentexperimental researchexperimental studyexperimentsexposed to cocaineexposure to cocainehistorieshormonal regulationhormonal signalshormone regulationhormone signalshuman immunodeficiency virus infectionhypothalamicimmune functionimprovedindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinhibitormedication adherencemedication compliancemouse modelmurine modelneuroactive steroidsneuronalneurosteroidsnovelovarian reservepeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople who use drugspeople who use illicit drugspeople with HIVpeople with human immunodeficiency viruspersons who use drugspre-clinicalpre-exposure prophylaxispreclinicalpreoptic regionprevent AIDSprevent human immunodeficiency virusprevent relapserelapse against cocainerelapse preventionsocial rolesubstance use and disordertherapeutic targettooltreat HIVtreat Human Immunodeficiency Virus♀
Description preview
Project Summary
Drug use increases HIV risk and worsens health outcomes in people living with HIV (PLWH). While antiretrovirals
are effective for both prevention – using pre-exposure prophylaxis (PrEP) – and for treatment – using
antiretroviral therapy (ART) – drug use further impairs medication adherence. It is thus essential to develop…
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